J INTERN MED: Fracture risk and subsequent mortality in patients with nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is a widespread disease associated with increased mortality
.

In addition, NAFLD is associated with type 2 diabetes , insulin resistance, chronic inflammation, low physical activity, and vitamin D deficiency, which may lead to decreased bone density

Diabetes Vitamin D Osteoporosis

The aim of this study was to determine fracture incidence, fracture risk, and post-fracture mortality in patients with NAFLD compared with the general population
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This is a population-based nationwide cohort study using data from the Swedish National Patient Registry of 10,678 patients with NAFLD from 1987-2016
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Patients were matched for sex, age, and city with 99,176 controls from the Swedish General Population Register

A total of 12,312 fractures occurred during 761,176 person-years of follow-up
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NAFLD patients (17.

CONCLUSIONS: Patients with NAFLD have a slightly higher incidence of fractures, but the long-term risk of fractures is comparable to the general population
.

This suggests that extensive monitoring of fracture risk factors in NAFLD patients is unnecessary

Fracture rates are slightly higher in NAFLD patients, but the long-term risk of fractures is comparable to the general population

Original source:

Axel Wester, et al.

Axel Wester, et al.
Risk of fractures and subsequent mortality in non-alcoholic fatty liver disease: Anationwide population-based cohort study .
Journal of Internal Medicine.
2022.
https://onlinelibrary.
wiley.
com/doi/10.
1111/joim.
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