J Patient Saf: Which antimicrobial interactions with sulfonylureas can cause hypoglycemia? How to respond?

It is estimated that the number of adults with diabetes worldwide (aged 20-79 years) increased from 151 million in 2000 to 463 million in 2019

A large cohort study comparing data from 102493 diabetic patients with 203518 non-diabetic control subjects found that diabetic patients all had higher rates of infection, particularly osteoarticular infection, sepsis, and cellulitis

There is growing evidence that antibiotics may cause changes in

Sulfonylureas are the second most common oral diabetes treatment, and studies have shown that a combination of sulfonylureas (SUs) and several antimicrobials increases the

The researchers analyzed the 2006-2016 U.

The results found that 2.

The risk of hypoglycemia associated with a combination of sulfonylureas and each antimicrobial

In addition, studies have found that when metformin is combined with SUs, the risk of developing hypoglycemia is higher than that of DPP4i

In summary, sulfonylureas and antimicrobial agents with potentially dangerous interactions are often used

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