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It is estimated that about one-third of human non-communicable chronic diseases and prenatal determinants related to heart blood vessel disease - one of the world's largest "killer", is no exception
It is estimated that about one-third of human non-communicable chronic diseases and prenatal determinants related to heart blood vessel disease - one of the world's largest "killer", is no exception
According to the report, the mother's use of antioxidant treatments such as vitamin C can prevent oxidative stress in the heart and blood vessels of the fetus, enhance NO signaling, and protect the offspring from the risk of cardiovascular dysfunction
Therefore, some researchers say that melatonin may be the main drug candidate to protect the fetal heart and blood vessels from oxidative stress and damage to NO signaling during development
Therefore, some researchers say that melatonin may be the main drug candidate to protect the fetal heart and blood vessels from oxidative stress and damage to NO signaling during development
This study was approved by the Animal Welfare and Ethics Review Committee of the University of Cambridge
In the last quarter of pregnancy in rats, there is evidence that the fetal aorta wall is thickened, the expression of cardiac eNOS protein is decreased, and the accompanying contractiles in the peripheral blood vessels in adulthood overreact to neurogenic and local agonists, resulting in postpartum catch-up growth.
Cardiovascular remodeling in fetus and adult offspring
Cardiovascular remodeling of the fetus and adult offspring Cardiovascular remodeling of the fetus and adult offspringThe mother is treated with melatonin at a dose slightly lower than the recommended dose to prevent the adverse effects of hypoxic pregnancy on the cardiovascular system of the fetus and adult offspring, but does not affect the changes in the fetus or postpartum growth
The mother is treated with melatonin at a dose slightly lower than the recommended dose to prevent the adverse effects of hypoxic pregnancy on the cardiovascular system of the fetus and adult offspring, but does not affect the changes in the fetus or postpartum growth
In conclusion, this study shows that the mother's low-dose melatonin treatment has a significant protective effect on the procedural adverse effects of the cardiovascular structure and function of the offspring of hypoxic pregnancy
References: Hansell, JA ,Richter, HG ,Camm, EJ , et al.
Maternal melatonin: Effective intervention against developmental programming of cardiovascular dysfunction in adult offspring of complicated pregnancy .
J Pineal Res .
2021 ; 00 :e12766.
https:// doi.
org/10.
1111/jpi.
12766 Hansell, JA , Richter, HG , Camm, EJ , et al.
Maternal melatonin: Effective intervention against developmental programming of cardiovascular dysfunction in adult offspring of complicated pregnancy .
J Pineal Res .
2021 ; 00:e12766.
https://doi.
org/10.
1111/jpi.
12766
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