J Rheumatol: Risk and consequences of vertebral fractures in patients with strong syllitis

The study was designed to compare long-term prevalence, morbidity and outcomes of vertebral fractures (
VF) in patients with strong syllitis (
AS) and matching control group, including the effects of out-of-the-joint manifestations (
EAM) andosteoporosisresearchers conducted a statewide observational study using2,321patients withASand22,976 controls on online health data from2,321 1980-2015 Data analysis was performed using morbidity (per 1000 years) and ratios (
IRR ), multifactory
Cox proportional risk regression, and Kaplan-Meier survival curve During the median follow-up 13.92 years (
IQR 7.58 , 2 1.67 ), the incidence of VF and new VF in patients of AS were higher than those of the control group (
9.3 percent vs 2.5 percent, 6.8 percent .9 percent, respective ly, Compared to the control group, the risk of VF in patients with AS was increased after adjusting age, sex, and osteoporosis (
HR s 2.55 ; 95 % CI : 2.11 , 3.09 ) and continued throughout the study period Patients with AS were younger 5 years old (
p-0.008 ) for the first time VF compared to the corresponding control group( and more likely to have VF again (
IRR ? 4.64; 95 % CI : 4.54 , 4.75 ) After adjusting for age, sex, osteoporosis and VF status, the overall mortality rate of AS patients was comparable to that of the control group (
HR ?0.90 ; 95 % CI : 0.80 , 1.01 ) began treatment TNFi , the significant increase dyslecostofability of VF in patients AS has not changed Although AS patients with first-
VF are younger than the control group, this does not increase the risk of death