J Rheumatol: Serum miRNA markers as diagnostic and therapeutic markers for psoriasis arthritis

MicroRNAs (miRNAs) are small endogenous regulatory RNA molecules that are now potential autoimmune therapy targets and biomarkersThe study looked at serum miRNA levels in patients with psoriasis arthritis (PsA) and further evaluated serum miRNA characteristics in patients with therapeutic and non-reactive patientscollect serum samples from patients with healthy controls (n?20) and PsA (n-31) and obtain clinical demography dataTo analyze circulating miRNA in the serum of HC and PsA patients, a concentrated immunological miRNA was analyzed using miRNA Fireplex analysisAccording to the EULAR response criteria, the miRNA expression of the reactive and non-reactivecompared to the healthy control, 6 miRNAs (miR-221-3p, miR-130a-3p, miR-14p) in PsA patients were further evaluated6a-5p, miR-151-5p, miR-26a-5p, and miR-21-5p) were significantly increased (p-average 0.05), and the specificity and sensitivity determined by the subject's working characteristics (ROC) curves were highAnalysis of the reactionors vs non-reactive showed that high baseline levels of miR-221-3p, miR-130a-3p, miR-146a-5p, miR-151-5p and miR-26a-5p were associated with therapeutic responsesthis study identified six serum miRNA markers that have the potential to become non-invasive markers of PsA and may help clarify the pathogenesis of the disease