JAAD: Does the menstrual cycle affect the severity of atopic dermatitis and psoriasis?

 

Atopic dermatitis (AD) is a multifactorial, chronic recurrence, itching, Th2 cytokine-driven skin disease
.

Type 2 cytokines including IL-4, IL-13 and IL-31 are also the main regulators of chronic pruritus

This is a longitudinal prospective study that recruited women aged 18 to 45 years with atopic dermatitis or psoriasis
.

Questionnaire surveys were conducted on their dermatological and gynecological characteristics, and they were evaluated before, during and after menstruation for 3 consecutive months

statistics

Overall, 169 women with atopic dermatitis (n, 87) or psoriasis (n, 82) were selected
.

Using chi-square or Fisher to accurately test categorical variables or continuous variables, AD and psoriasis patients only differed in age of onset, course of disease, area of ​​skin involvement, and comorbidities

The main result of this study is that compared with the menstrual period, the disease severity, itching, and quality of life of moderate to severe AD patients deteriorated significantly before menstruation, and what is more, compared with the postmenstrual period: eczema area and severity index (EASI) the average deterioration was 17.
7%, the most severe pruritus on the Numerical Rating Scale (NRS) deteriorated by 35.
3%, and the Dermatological Quality of Life Index (DLQI) was 26.
3%
.

The Cox multiple regression model was used to evaluate the aggravation of premenstrual AD through the difference of EASI, pruritus-NRS and DLQI before and after menstruation, which is related to higher age at menarche and longer menstrual cycle

Quality of Life

All in all, a large number of women of childbearing age who suffer from AD experience aggravation of the disease before menstruation
.

These aspects are worth noting in order to more fully manage patients and recruit patients in clinical trials

manage

 

Literature source: Dal Bello G, Maurelli M, Schena D, Variations of symptoms of atopic dermatitis and psoriasis in relation to menstrual cycle, J Am Acad Dermatol 2021 Dec 14;

Dal Bello G, Maurelli M, Schena D, Variations of symptoms of atopic dermatitis and psoriasis in relation to menstrual cycle, J Am Acad Dermatol 2021 Dec 14;

 

 

 

Leave a message here