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The accumulation of somatic DNA mutations is a sign of aging in many tissues.
stem cell
In population-based studies and patients with ischemic heart failure (HF) and reduced left ventricular ejection fraction (LVEF), clonal hematopoiesis driven by somatic mutations in hematopoietic cells is often referred to as uncertain potential clonal hematopoiesis (CHIP), and medsci.
Uncertain potential of clonal hematopoietic (CHIP), and medsci.
To evaluate the clinical impact of clonal hematopoiesis on the progression of heart failure of different etiologies
The study cohort included 62 HF patients with LVEF<45% (74±7 years old, 74% male, 52% non-ischemic, LVEF 30±8%).
62 HF patients with LVEF<45%
CHIP mutations detected
CHIP mutations detectedOverall, 24 patients (38.
CHIP mutations were detected in 24 patients (38.
Correlation between CHIP mutations and hospital survival rate without HF
Correlation between CHIP mutations and hospital survival rate without HFIn single gene specific analysis, somatic mutations in DNMT3A or TET2 have a certain prognostic significance for HF-related death or hospitalization (DNMT3A mutation: HR 4.
Somatic mutations in DNMT3A or TET2 have certain prognostic significance for HF-related death or hospitalization
In summary, the somatic mutations driving clonal hematopoiesis are common in HF patients with reduced LVEF and are associated with accelerated progression of HF, regardless of the cause of HF.
Somatic mutations that drive clonal hematopoiesis are common in HF patients with reduced LVEF and are associated with accelerated progression of HF
Original source:
Original source:Pascual-Figal Domingo A,Bayes-Genis Antoni,Díez-Díez Miriam et al.
org/10.
1016/j.
jacc.
2021.
02.
028" target="_blank" rel="noopener">Clonal Hematopoiesis and Risk of Progression of Heart Failure With Reduced Left Ventricular Ejection Fraction in this message