JAHA: Association between body mass index and cardiovascular outcomes in patients with stable coronary heart disease

The obesity paradox states that patients with higher body mass index (BMI) may have better cardiovascular outcomes
.
However, whether this is also the case for patients with coronary heart disease is unclear

Recently, a research article was published in JAHA, an authoritative journal in the field of cardiovascular disease.
The prospective STABILITY (Stable Atherosclerotic Plaque with Dalapradib) trial included 15,828 patients with stable coronary heart disease.
Subjects on primary prevention therapy were followed for 3 to 5 years
.

Subjects' BMI was measured at baseline (n = 15,785) and the association between BMI and cardiovascular outcomes was assessed by multivariate-adjusted Cox regression analysis
.

The mean age of the subjects was 64±9 years, and 19% were female
.
There was a graded association between most risk markers ( diabetes , hypertension , inflammatory biomarkers, triglycerides) and higher BMI

CONCLUSIONS: Cardiometabolic and inflammatory risk factors in patients with stable coronary heart disease gradually increased with BMI>25kg/m2
.
All-cause and cardiovascular mortality were lowest at a BMI of 25 to 35 kg/m2

Claes Held.