JAHA: Cardiometabolic, lifestyle and nutritional factors related to varicose veins

Recently, the heart blood vessels published on the prestigious journal JAHA the areas of disease research article, researchers conducted a two-sample Mendelian randomized study to evaluate the association between cardiac metabolism, life>
.

Researchers will compare height (positive control), body mass index, type 2 diabetes , diastolic and systolic blood pressure, smoking, alcohol and coffee intake, 7 circulating vitamins (A, B6, B9, B12, C, 25- hydroxyvitamins) D and E) and five circulating minerals (calcium, iron, magnesium, selenium, and zinc) were used as instrumental variables at the level of genome-wide significance
.
The summary data of genetic association with varicose veins comes from the British Biobank (8763 cases and 352,431 non-cases) and the FinnGen Alliance (13928 cases and 153951 non-cases)

Higher genetics predict that height, body mass index, smoking, and circulating iron levels are associated with an increased risk of varicose veins
.
The odds ratio (OR) for each SD increase in exposure is 1.

Higher genetic predicted systolic blood pressure and circulating calcium and zinc levels were associated with a reduced risk of varicose veins, and after adjusting for genetic predicted height, the correlation of systolic blood pressure did not persist
.
For every SD increase in blood calcium level, the OR is 0.

Thus, this study identified several modifiable risk factors for varicose veins
.

Original source:

Shuai Yuan.