JAHA: correlation between age of onset of hypertriglyceridemia and cardiovascular disease and all-cause mortality in adults

Cardiovascular disease (CVD) remains the leading cause of adult mortality worldwide, and lipid metabolism disorders are important risk factors for
CVD development and all-cause mortality.
The trend towards the onset of lipid metabolism disorders is consistent with the increasing incidence of CVD in younger individuals at a younger age, but research on new-onset hypertriglyceridemia is limited
.

Recently, JAHA, an authoritative journal in the field of cardiovascular diseases, published a research article to evaluate the relationship
between the age of onset of hypertriglyceridemia and cardiovascular disease (CVD) and all-cause mortality.

This population-based prospective study included 98,779 participants
from baseline without hypertriglyceridemia and cardiovascular disease in the Kailuan study initiated in June 2006.
All participants underwent health check-ups every two years, and until December 2017, a total of 13,832 participants developed new hypertriglyceridemia
.
Using a 1:1 analysis of age (± 1 years) and sex matching, the researchers selected control subjects
for each new case in the same year.
A total of 13,056 case-control
pairs were included in the study.
The total follow-up was 179409 per year, with a median follow-up of 7.
0 years
.
The primary outcomes of the study were cardiovascular disease and all-cause mortality, with an estimated risk ratio
adjusted for baseline characteristics.

A total of 807 cardiovascular disease events and 600 all-cause deaths were recorded
in the study.
After multivariate adjustment, participants with age of onset of hypertriglyceridemia < 45 years had the highest risk compared with matched controls, with a hazard ratio of 2.
61 (95% CI 1.
59 to 4.
27), an all-cause mortality ratio of 4.
69 (95% CI 2.
34 to 9.
40), a hazard ratio of 2.
23 (95% CI 0.
67 to 7.
38), and a risk ratio of stroke of 2.
68 (95% CI 1.
56 to 4.
62)
。 Risk estimates decrease gradually as
the age of onset of hypertriglyceridemia increases.

It can be seen that early onset of hypertriglyceridemia is associated
with a higher risk of cardiovascular disease and all-cause mortality in Chinese adults.

Original source:

Hui Zhou,et al.
Associations of Hypertriglyceridemia Onset Age With Cardiovascular Disease and All‐Cause Mortality in Adults: A Cohort Study.
JAHA.
2022.
JAHA.
122.
026632