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    Home > Active Ingredient News > Digestive System Information > JAHA: The relationship between deoxycholic acid and coronary artery calcification in patients with chronic renal insufficiency

    JAHA: The relationship between deoxycholic acid and coronary artery calcification in patients with chronic renal insufficiency

    • Last Update: 2022-04-23
    • Source: Internet
    • Author: User
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    Vascular calcification is common in chronic kidney disease (CKD)
    .


    66% of the chronic renal insufficiency cohort (CRIC) study participants exhibited moderate to severe coronary artery calcification (CAC)


    Vascular prevention

    Deoxycholic acid (DCA) is a secondary bile acid that has been reported to promote vascular calcification
    .


    In a small subset of individuals with advanced chronic kidney disease, higher DCA levels are associated with common coronary artery calcification (CAC)


    A multivariate adjusted regression model was used to assess the relationship between fasting serum DCA levels and computed tomography CAC in the Chronic Renal Insufficiency Cohort (CRIC) study.
    Cross-sectional (n=1057) and longitudinal (n=672) correlations
    .

    The mean age of the subjects was 57±12 years, 47% were female, and 41% were black
    .


    At baseline, 64% of subjects had CAC (CAC score >0 Agatston units)


    statistics

    CONCLUSIONS: Among CRIC study participants, DCA was not associated with the prevalence, incidence, or progression of CAC
    .

    Among CRIC study participants, DCA was not associated with the prevalence, incidence, or progression of CAC
    .


    Original source:

    Original source:

    Anna Jovanovich, et al.


    Deoxycholic Acid and Coronary Artery Calcification in the Chronic Renal Insufficiency Cohort .
    JAHA.



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