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Vascular calcification is common in chronic kidney disease (CKD)
.
66% of the chronic renal insufficiency cohort (CRIC) study participants exhibited moderate to severe coronary artery calcification (CAC)
Vascular prevention
Deoxycholic acid (DCA) is a secondary bile acid that has been reported to promote vascular calcification
.
In a small subset of individuals with advanced chronic kidney disease, higher DCA levels are associated with common coronary artery calcification (CAC)
A multivariate adjusted regression model was used to assess the relationship between fasting serum DCA levels and computed tomography CAC in the Chronic Renal Insufficiency Cohort (CRIC) study.
Cross-sectional (n=1057) and longitudinal (n=672) correlations
.
The mean age of the subjects was 57±12 years, 47% were female, and 41% were black
.
At baseline, 64% of subjects had CAC (CAC score >0 Agatston units)
statistics
CONCLUSIONS: Among CRIC study participants, DCA was not associated with the prevalence, incidence, or progression of CAC
.
.
Original source:
Original source:Anna Jovanovich, et al.
Deoxycholic Acid and Coronary Artery Calcification in the Chronic Renal Insufficiency Cohort .
JAHA.