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JAMA Intern Med: Oral Daprodustat regimen for anemia in chronic kidney disease

 Last Update: 2022-04-15
 Source: Internet
 Author: User

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Statistics found that the risk of death in the first 90 days after starting dialysis was twice as high as that in the following 9 months

Statistics Recently, researchers investigated the efficacy of oral hypoxia-inducible factor prolyl hydroxylase inhibitor Daprodustat in patients with recent CKD dialysis anemia

The study was conducted in 90 clinical centers in 14 countries, and patients with advanced CKD who started receiving hemodialysis (HD) or peritoneal dialysis (PD) 90 days before the start of the study participated, and the patient's hemoglobin (Hb) concentration was 8.

Of the 312 patients enrolled, mean age 55 years, 62% male, 157 received daprodustat and 155 received dabebor alfa, and 306 (98%) completed the study

The HD concentration during the evaluation period was 10.

Changes in HD level and iron injection amount between groups

The study concluded that Daprodustat is an effective oral erythropoiesis-stimulating treatment regimen for patients with anemia in chronic kidney disease as effective as dabepox alfa

Daprodustat is an effective oral erythropoiesis-stimulating treatment regimen that is comparable to dabepog alfa in patients with anemia in chronic kidney disease

Original source:

Ajay K.

Efficacy and Safety of Daprodustat for Treatment of Anemia of Chronic Kidney Disease in Incident Dialysis Patients A Randomized Clinical Trial JAMA

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