JAMA Netw Open: History of spontaneous or induced abortion and the risk of gestational diabetes mellitus

Background: Gestational diabetes mellitus (GD) is one of the most common and important complications of pregnancy, affecting 7% to 25% of all clinically recognized pregnancies worldwide
.

The high prevalence of gestational diabetes is of great concern because it is not only associated with poor perinatal outcomes, but also with increased long-term cardiovascular and metabolic health risks for mothers and their children

Gestational diabetes (GD) is one of the most common and important complications of pregnancy, affecting 7% to 25% of all clinically confirmed pregnancies worldwide

Abortions, which can be accidental or intentional, are common across the globe

Design, setting, and participants: This retrospective cohort study was conducted in a tertiary hospital in Shanghai, China
.

Pregnant women who received routine antenatal care between January 2014 and December 2019 were included

Exposure: History of maternal abortion, including SAB and induced abortion, extracted from medical records
.

Main results and indicators: GD was diagnosed by 75g anhydrous glucose tolerance test
.

Multivariate-adjusted log-binomial analysis was used to estimate the relative risk (RR) and 95% CI for GD associated with a history of miscarriage

RESULTS: Among 102 259 pregnant women, 14579 (14.
3%) had only a history of SAB, 17935 (17.
5%) had a history of induced abortion, and 4017 (3.
9%) had both SAB and induced abortion
.

There were 12 153 GD patients in the cohort, and the prevalence of GD was 11.

Table 1.
General characteristics of pregnant women by history of miscarriage

Table 1.
General characteristics of pregnant women by history of miscarriage

Table 2.
Distribution of blood glucose levels at 24 to 28 weeks of pregnancy by history of miscarriage

Table 2.
Distribution of blood glucose levels at 24 to 28 weeks of pregnancy by history of miscarriage

Table 3.
Relationship between GD events and abortion history

Table 3.
Relationship between GD events and abortion history

Figure 1.
Association between the number of spontaneous abortions (SAB) and the risk of gestational diabetes

Figure 1.
Association between the number of spontaneous abortions (SAB) and the risk of gestational diabetes

Conclusions: This study found that a history of SAB was associated with an increased risk of developing GD in another pregnancy
.

Further research is needed to clarify this link and to explore the underlying biological mechanisms behind it

This study found that a history of SAB was associated with an increased risk of developing GD in another pregnancy

Association of History of Spontaneous or Induced Abortion With Subsequent Risk of Gestational Diabetes JAMA Leave a Comment here