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With the in-depth study of the pathogenesis of intestinal mucosal immunopathology , biological agents have brought new dawn to the clinical treatment of IBD, mainly including targeted blocking of various pro-inflammatory cytokines (such as TNF-α, IL-12/IL-23), and inhibit the migration of activated leukocytes to the intestinal mucosa (such as integrin α4β7)
With the in-depth study of the pathogenesis of intestinal mucosal immunopathology , biological agents have brought new dawn to the clinical treatment of IBD, mainly including targeted blocking of various pro-inflammatory cytokines (such as TNF-α, IL-12/IL-23), and inhibit the migration of activated leukocytes to the intestinal mucosa (such as integrin α4β7)
The cohort included in this study is a national Israeli cohort study called Epi-IIRN.
Since 2005, a total of 13,231 patients have been diagnosed with UC in Israel (1,426 [11%] are children , 10,310 [78%] are adults, and 1,495 [11%] are elderly), with a total follow-up time of 93675 Man year
child
This study confirmed that although with the advent of the era of biological agents, the surgical rate and steroid dependence rate of UC patients remained unchanged, while the hospitalization rate decreased slightly
This study confirmed that although with the advent of the era of biological agents, the surgical rate and steroid dependence rate of UC patients remained unchanged, while the hospitalization rate decreased slightly
Ohad Atia.
Colectomy rates did not decrease in pediatric- and adult-onset ulcerative colitis during the biologics era-a nationwide study from the epi-IIRN.
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