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JCC: The overexpression of vitamin D receptors in the intestinal epithelium can prevent the occurrence of colitis by up-regulating the tight junction protein Claudin-15

 Last Update: 2021-04-22
 Source: Internet
 Author: User

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Vitamin D receptor (VDR) dysfunction is involved in the pathogenesis of IBD by regulating autophagy, immune response and mucosal permeability.

Researchers collected intestinal specimens from patients with ulcerative colitis and analyzed the correlation between Claudin-15 expression and the reduction of VDR in colitis.

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In human specimens, the researchers found that the decreased expression of Claudin-15 in colonic epithelial cells of patients with IBD was significantly related to the abnormal function of VDR.

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Figure: The role of claudin-15 in colitis

Human experiments and mouse experiments have proved that the VDR-dependent claudin-15 up-regulation mechanism can prevent the occurrence of colitis.

Original source:

Ishita Chatterjee.

oup.
com/ecco-jcc/advance-article-abstract/doi/10.
1093/ecco-jcc/jjab044/6159780?redirectedFrom=fulltext" target="_blank" rel="noopener">Overexpression of Vitamin D Receptor in Intestinal Epithelia Protects Against Colitis via Upregulating Tight Junction Protein Claudin 15.
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