JCEM: Association between the use of antidepressants and the outcome of advanced diabetes in patients with depression and diabetes

Diabetes patients with depression will worsen the patient's outcome
.
Antidepressants may reduce the adverse effects of depression; however, they are associated with adverse cardiometabolic reactions

Recently, the Journal of Clinical Endocrinology & Metabolism, an authoritative journal in the field of endocrine and metabolic diseases, published a research article that aims to explore the relationship between antidepressant treatment and advanced diabetes complications and mortality in patients with depression and diabetes
.

Researchers used the Taiwan National Health Insurance database to identify 36,276 depression and newly treated depression patients to conduct a nationwide retrospective cohort study
.
The antidepressant treatment mode within the 6-month window is divided into no, poor compliance, partial use, and routine use.

Cox model estimated risk ratio for the outcome of advanced diabetes

Compared with poor compliance with antidepressants, regular use of antidepressants is associated with a 0.
92 times reduction in the risk of macrovascular complications and a 0.
86 times reduction in the risk of all-cause death, but it has nothing to do with microvascular complications
.
Routine use of selective serotonin reuptake inhibitors can reduce the risk of macrovascular complications and all-cause mortality by 0.

Thus, compared with poor compliance, regular use of antidepressants is associated with a lower risk of late-stage diabetes complications
.
Clinicians should emphasize the compliance of antidepressant treatment in patients with depression and diabetes