JCEM: Early adulthood hyperandrogenemia is an independent risk factor for abnormal glucose metabolism in middle-aged

The role of female excessive androgen as a promoting factor of abnormal glucose metabolism (AGM) and insulin resistance is still controversial
.

Recently, a research article was published in the Journal of Clinical Endocrinology & Metabolism, an authoritative journal in the field of endocrine and metabolic diseases, which aims to explore the passage of serum testosterone (T) levels and free androgen index (FAI) at the age of 31 and 46.
Evaluate whether the hyperandrogenemia (HA) is related to insulin resistance, insulin secretion, and AGM at 46 years of age
.

The prospective study included 5889 women who were followed up at 31 and 46 years of age
.

At the age of 31, after adjusting the body mass index (BMI), compared with normal androgen women, HA women had higher HOMA-IR (P=0.
05), HOMA-B (P=0.
006) and fasting insulin (P=0.
034)
.

It can be seen that early and middle age hyperandrogenemia and low SHBG are related to AGM, but not to BMI

Original source:

Katri Tuorila.