JCEM: Effects of Vitamin D Supplements on Fall Risk

It is not clear whether vitamin D supplementation will reduce the risk of falls, and the results of randomized controlled trials (RCTs) are contradictoryA recent study published in journal Journal of Clinical Endocrinology and Metabolism, an authoritative journal in the field of endocrinology and metabolic diseases, aims to determine whether 2000 IU vitamin D3 supplements per day reduce the risk of fallsThe VITamin D and OmegA-3 trial (VITAL) was a placebo-controlled double-blind RCT containing 25,871 adults who were treated at random grouping spent 5.3 years (median) between November 2011 and March 2014Participants were at the age of 50 years old without cancer or cardiovascular disease when the participants were at the baseline and 55 years of age (average age is 67.1 years)Interventions were vitamin D3 (cholecalcidrol; 2000 IU/day) and/or omega-3 fatty acids (1 g/day) or corresponding placebo, with a 2X2 progenitor designThe study's main observations were two or more visits due to falls and fallsthe baseline serum total 25-hydroxy vitamin D (25 (OH)D) level is 77nmol/L; The number of participants who fell in the intervention group and the placebo group was similar (9.8% vs9.4%)In the past 5 years, the proportion of falls of 2 (OR-0.97; 95% CI is 0.90-1.05, p-0.50), falls lead to visits (OR-1.03; 95% CI is 0.94-1.13, p-0.46) or hospitalization (1.04; 95% CI is 0.90-1.19, 0.pThere is no difference in the results of baseline 25 (OH) D.50 vs50 nmol/L or other critical pointsdaily vitamin D3 supplementation did not reduce the risk of falls compared to placebo sauors in general healthy adults who did not choose vitamin D deficiencySuch a large RCT does not support vitamin D supplementation to prevent falls