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Coinciding with the childhood obesity epidemic, chronic metabolic diseases such as type 2 diabetes and nonalcoholic fatty liver disease (NAFLD) are on the rise among adolescents
.
Although the behavioral and biological underpinnings are complex and multifaceted, a "Western diet" high in refined carbohydrates and unhealthy fats is considered a key behavioral risk factor
Diabetic nonalcoholic fatty liver disease in children
Recently, a research article was published in the Journal of Clinical Endocrinology & Metabolism, an authoritative journal in the field of endocrine and metabolic diseases.
The researchers aimed to evaluate the serum endotoxin biomarker LPS and its binding protein, LPS-binding protein (LBP) and anti-endocrinopathy.
Prospective associations between toxin core IgG and adolescent obesity and cardiometabolic risk
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This prospective study included 393 youth in the Colorado EPOCH cohort
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Participants were recruited in 2006-2009 with a mean age of 10 years (baseline) and were followed for six years (follow-up)
Higher LPS and LBP predicted higher adiposity during follow-up
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Each 1-unit ln conversion of LPS corresponds to a BMIz score of 0.
Thus, serum endotoxin may be a marker of the pathophysiological process of childhood obesity and cardiometabolic diseases related to fetal overnutrition
.
.
Original source:
Original source:Wei Perng, et al.
Endotoxin biomarkers are associated with adiposity and cardiometabolic risk across 6 years of follow-up in youthLeave a message here
