JCEM: Hypothalamus gland dysfunction women with anti-Mueller tube hormone levels and ovarian morphology

Women with hypothalamus adenorate (HH) have different phenotype characteristics, including ovarian morphology, but are rarely described in large queuesSeveral studies have reported elevated levels of anti-Mueller tube hormone (AMH) in HH patientsRecently, the authoritative journal Journal of Endocrinology and Metabolic Diseases published a study in the journal Journal of Clinical Endocrinology and Metabolism to assess whether serum AMH levels in HH patients were elevated compared to the health control group, and how many of these patients were incorrectly diagnosed with polycystic ovary syndrome (PCOS) as determined by the Rotterdam diagnostic criteriathe retrospective cohort study conducted at the Dutch Teaching Medical Centre included 83 women with neither ovulation disorder or menstrual cycle disorder (health control), 159 HH women and 3,640 PCOS womenThe 2nd queue was created using an age match (a 1:2 ratio) between the HH group and the PCOS group, consisting of 318 age matching PCOS womenThe main outcome indicators of the study were AMH levels and ovarian morphologyThe median aMH level in Group HH was 3.8 (0.1-19.8), the PCOS group was 7.5 (0.1-81.0) and the control group was 1.9 (0.1-21.5) (p 0.001)In the HH group, 58 people (36%) were incorrectly diagnosed with polycystic ovary syndrome (2 of the three Rotterdam diagnostic criteria), the ausay is seen as an increase in AMH levels in HH patientsThe researchers speculated that this increase, although not increased the follicle count, may have been due to the presence of a relatively large pool of sinus-shaped follicles less than 2mm in diameter, which could not be detected by vaginal ultrasoundThis study highlights the importance of measuring gonadotropins and estradiol (E2) before diagnosing polycystic ovary syndrome