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JCEM: Low progesterone and estradiol are associated with male abdominal aortic aneurysms

 Last Update: 2021-12-26
 Source: Internet
 Author: User

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Males are the main risk factor for abdominal aortic aneurysm, but few studies have explored the association between sex hormone levels and abdominal aortic aneurysm
.

Recently, a research article was published in the Journal of Clinical Endocrinology & Metabolism, an authoritative journal in the field of endocrine and metabolic diseases.
The study aimed to describe the relationship between serum sex hormone levels and abdominal aortic aneurysms detected by early screening in men
.

Screening

The researchers used a validated high-sensitivity liquid chromatography-tandem mass spectrometry method to comprehensively analyze the serum sex hormone levels
.

This detection method was then used in a case-control study, which included 147 men with abdominal aortic aneurysm (≥30 mm below the branch of the aortic renal artery) and 251 controls without abdominal aortic aneurysm.

Men with abdominal aortic aneurysms have lower levels of dehydroepiandrosterone, progesterone, 17α-hydroxyprogesterone, testosterone, and estradiol, but the levels of other hormones have not decreased
.

In the model that adjusted for known risk factors and comorbidities of abdominal aortic aneurysm, only progesterone (the odds ratio for each reduction in SD was 1.

It can be seen that through high-performance sex hormone testing methods, progesterone and estradiol are negatively correlated with male abdominal aortic aneurysms, and have nothing to do with known risk factors
.

Future research should explore whether progesterone and estradiol have protective effects on human abdominal aortic aneurysms

Progesterone and estradiol are negatively correlated with male abdominal aortic aneurysms and have nothing to do with known risk factors

Original source:

Claes Ohlsson.

Low Progesterone and Low Estradiol Levels Associate with Abdominal Aortic Aneurysms in Men in this message

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