JCEM: Serum serotonin as a new predictor of brittle fractures

Metabolomics is an emerging tool that provides information about the dynamics of esolysal changes.
metabolomics is a potential means of discovering new fractured serum markers.
recently, a study published in Journal of Clinical Endocrinology and Metabolism, an authoritative journal in the field of endocrine and metabolic diseases, aims to identify metabolite parameters that can be used as a risk of osteoporosis fractures.
the study was based on a forward-looking study of South Korea's Aeson cohort, in which 1,504 individuals were analyzed for metabolomics.
the main indicator of the study was brittle fractures.
researchers measured 135 metabolites in the participants' fasting serums.
age of participants was 60.2 years, including 585 men (38.9 per cent).
112 osteoporosis fractures occurred during an average of nine years of follow-up.
After adjusting for age, sex, BMI, diabetes, hypertension, smoking status, past fracture history and baseline tibia quantitative ultrasound, only serum subselamide concentration was positively associated with fracture risk in all metabolites measured (The corresponding risk ratio for each 1 m subselam is 1.35, 95% confidence interval of 1.03-1.65, p, 0.020).
participants with an adjusted concentration of ≤1.57 m) had a higher risk of fractures (2.2%) (95% CI of 1.08-4.51, p=0.030) than participants with an adjusted concentration of 1.57μM.
in the subgroup analysis, the risk of fractures was also 2.4 times higher in women with baseline subsethamine concentrations of 1.57 m than in women with concentrations of ≤1.57?M (95% CI was 1.02-5.48, p=0.047).
result, an increase in baseline subsemination concentration was associated with a risk of osteoporosis fractures during an average of 9 years of follow-up.