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JCEM: The effect of low-dose gliclazide on incretin and β-cell function

 Last Update: 2021-03-21
 Source: Internet
 Author: User

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Neonatal diabetes studies have shown that sulfonylureas can lower blood sugar without causing hypoglycemia, partly because it enhances the effect of incretin.

Diabetic hypoglycemia

Recently, a research article was published in the Journal of Clinical Endocrinology & Metabolism, an authoritative journal in the field of endocrine and metabolic diseases.

Researchers performed a paired oral glucose tolerance test and isobaric infusion on 16 patients with type 2 diabetes (HbA1c<64mmol/mol, 8.

Metformin

A single dose of 20 mg gliclazide reduced the average blood glucose concentration during OGTT from 12.

It can be seen that low-dose gliclazide can lower blood sugar and at the same time enhance the effect of classic incretin .

Low-dose gliclazide can lower blood sugar and at the same time enhance the effect of classic incretin

Original source:

Ruth LM Cordiner.

org/10.
1210/clinem/dgab151" target="_blank" rel="noopener">The impact of low dose gliclazide on the incretin effect and indices of beta cell function in this message

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