JCEM: The Effects of Dinner Time on Healthy People's Metabolism

Calorie consumption at night is associated with obesity and metabolic syndromeIn a recent study published in the journal Journal of Endocrine and Metabolic Diseases, researchers hypothesized that late dinner changes the metabolism of the underlying nutrients in sleep, thereby promoting obesity, and assessing the effects of dinner time on nighttime metabolism among healthy volunteersthis randomized cross-test compared the metabolic effects of late dinner (LD, 22:00) with regular dinner (RD, 18:00) in a laboratory environment with a fixed sleep time (23:00-07:00)20 healthy volunteers (10 men and 10 women) with an age of 26.0 to 0.6 years and a BMI of 23.2 to 0.7 kg/m2, accustomed to falling asleep at 22:00-01:00Volunteers gave a large amount of nutrients in both visitsOral lipid tracers are used at 18:00 in RD (35% of the daily large car, 50% carbohydrate, 35% fat) and 22:00 for LD with oral lipid tracers (2H31, palmate, 15 mg/kg, respectively)The study's main observations were plasma glucose, insulin, triglycerides, free fatty acids (FFA), cortisol, dietary fatty acid oxidation, and overnight polysemy charts per hour at night and the next morningLD causes the after-meal period to shift back 4 hours, overlapping with the sleep stageUnrelated to this change, LD's post-meal period was characterized by high glucose, triglyceride peak delay, lower FFA and dietary fatty acid oxidationLD does not affect the sleep structure, but increases plasma cortisol levelsThese metabolic changes were most pronounced in habitual early sleepers measured by behavioral tracing, it can be seen that LD causes poor night glucose tolerance and reduces oxidation and mobilization of fatty acids, especially in early sleepersThese effects, if long-term, may contribute to obesity