JCEM: The relationship between thyroid hormones and bone density.

There is growing evidence that thyroid hormone (PTH) is involved in the development of osteoporosis.
, the causal relationship between PTH and bone density (BMD) is not yet clear.
recently, a research paper was published in Journal of Clinical Endocrinology and Metabolism, an authoritative journal in the field of endocrine and metabolic diseases, to explore the relationship between serum PTH concentration and BMD.
of PTH is selected from a large-scale genome-wide association study (GWAS).
results include the forearm (FA), the femur neck (FN), the lumbar spine (LS), the BMD of the heel (HL), and the risk of fractures to these bones (n=361194).
addition, the researchers extracted BMDs of five age groups from the GHUAS meta-analysis study; 15 years of age or younger, 15-30, 4180, 30-45, 45-60, 18805, and over 60 years of age.
used two samples of Mendel Random (MR) for analysis.
MR analysis showed a negative correlation between serum PTH levels and FA (95% CI:-0.669 to -0.304), FN (95% CI:-0.669 to -0.304), and LS (95%CI:-0.667 to -0.243) BMD.
30-45 years old (95% CI: -0.888 to -0.166), 45-60 (95% CI:-0.75) A causal relationship was observed between serum PTH levels and BMD in populations 8 to -0.232) and over 60 years of age (95% CI:-0.649 to -0.163).
study showed a negative correlation between serum PTH concentrations and BMD in several bones.
further analysis showed a site-to-age correlation between serum PTH levels and BMD, which meant that high serum PTH levels promoted the development of osteoporosis.
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