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Lymphopenia is a key feature of immune dysfunction in patients with bacterial sepsis and COVID-19 , and is associated with poor clinical outcomes, but the cause is largely unknown.
COVID-19 immunity
Recently, a research article was published in the Journal of Clinical Endocrinology & Metabolism, an authoritative journal in the field of endocrine and metabolic diseases, which aims to evaluate the correlation between abnormal thyroid function and lymphopenia in patients with severe infection .
infection
Researchers retrospectively analyzed two independent hospitalized study populations: absolute lymphocyte counts, circulating TSH, T4, free T4 (FT4), T3, bacterial sepsis (224 cases) and COVID-19 patients (161 cases) Albumin and inflammation biomarkers.
Among patients with bacterial sepsis, only T3 was significantly correlated with lymphocyte count (rho=0.
It can be seen that in patients with severe infections such as bacterial sepsis and COVID-19, abnormal thyroid function is associated with lymphopenia, but future research needs to determine whether there is a causal relationship .
In patients with severe infections such as bacterial sepsis and COVID-19, abnormal thyroid function is associated with lymphopenia, but future research needs to determine whether there is a causal relationship
Original source:
Original source:Inge Grondman.
org/10.
1210/clinem/dgab148" target="_blank" rel="noopener">The association of TSH and thyroid hormones with lymphopenia in bacterial sepsis and COVID-19 in this message