JCI: Shen Zhanlong's team from Peking University People's Hospital reveals the mechanism of action of Asian-specific IgG1 memory B cell antigen receptor variants in the microenvironment of colorectal cancer

On March 15, 2022, Shen Zhanlong's research group from the Department of Gastrointestinal Surgery of Peking University People's Hospital and Liu Wanli's research group from the Institute of Immunology , School of Life Sciences, Tsinghua University cooperated to tackle key problems in the field of IgG1 memory B lymphocytes regulating the immune microenvironment of colorectal tumors .

The importance of T cells in tumor immune evasion and as a target for drug therapy has been recognized, but relatively little research has been done on B cells

The researchers conducted epidemiological analysis on a cohort of more than 1,000 colorectal cancer patients and found that tumor patients with the hIgG1-G396R homozygous genotype can significantly improve overall prognosis and survival and progression-free survival.

The above studies indicate that the hIgG1-G396R variant may be an important protective prognostic factor for patients with colorectal cancer, revealing that hIgG1-G396R has the potential to be used as a prognostic indicator for patients in the field of colorectal cancer, and provide reference for patient survival prediction, medication guidance, etc.

Dr.

 Schematic illustration of the IgG1 memory B-cell antigen receptor membrane-linked heavy chain hIgG1-G396R variant remodeling the colorectal cancer tumor microenvironment and enhancing antitumor immunity

Expert introduction

Shen Zhanlong, Chief Physician, Professor, Doctoral Supervisor of Gastrointestinal Surgery, Peking University People's Hospital, Deputy Director of the Surgical Oncology Laboratory

Original source:

Yang B, Zhang Z, Chen X, Wang XY, Qin S, Du L, Yang C, Zhu L, Sun W, Zhu Y, Zheng Q, Zhao S, Wang Q, Zhao L, Lin Y, Huang J, Wu F , Lu L, Wang F, Zheng W, Zhou XH, Zhao X, Wang Z, Xiao-Lin S, Ye Y, Wang S, Li Z, Qi H, Zhang Z, Kuang DM, Zhang L, Shen Z, Liu W .