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According to reports, ultra-high resolution (UHR) HLA matching can improve the effect of hematopoietic cell transplantation from unrelated donors, increase survival rate, and reduce post-transplant complications.
Recently, a new article " Impact of Previously Unrecognized HLA Mismatches Using Ultrahigh Resolution Typing in Unrelated Donor Hematopoietic Cell Transplantation " published in " J Clin Oncol " reported the results of a large multi-center validation study.
J Clin Onco J Clin Onco Impact of Previously Unrecognized HLA Mismatches Using Ultrahigh Resolution Typing in Unrelated Donor Hematopoietic Cell Transplantation
The study analyzed 5140 patients with 10/10 HLA-matched malignant tumors who underwent hematopoietic stem cell transplantation routinely with UHR HLA matching between 2008 and 2017 .
stem cell
After UHR HLA matching, 82% of matched patients still had 10/10 UHR concord, and 12.
Compared with 12/12 UHR-matched patients, UHR mismatched patients and HLA-DPB1 T cell epitopes allowed mismatched or disallowed mismatched patients developed grade 2-4 acute graft-versus-host disease (AGVHD) The probability of significantly increased (total P<0.
Cumulative incidence of TRM in the T cell depletion cohort
Cumulative incidence of TRM in the T cell depletion cohortIn the subgroup of patients with T cell depletion, the degree of UHR HLA mismatch was only related to an increase in transplant-related mortality (TRM) (total P=0.
In the subgroup of patients with T cell depletion, the degree of UHR HLA mismatch was only related to an increase in transplant-related mortality (TRM) (total P=0.
This study does not confirm that 12/12 UHR HLA compatibility can increase the overall survival rate of patients with hematopoietic stem cell transplantation from unrelated donors, but it confirms that 12/12 UHR HLA compatibility is associated with a reduced risk of aGVHD
Original source:
Original source:Mayor Neema P,Wang Tao,Lee Stephanie J et al.
org/10.
1200/JCO.
20.
03643" target="_blank" rel="noopener">Impact of Previously Unrecognized HLA Mismatches Using Ultrahigh Resolution Typing in Unrelated Donor Hematopoietic Cell Transplantation in this message
