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JEADV: Secretory leukoproteinase inhibitor modulates neuroreflex-mediated skin barrier function in psoriasis

 Last Update: 2022-04-17
 Source: Internet
 Author: User

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Lack of understanding of the early stages of psoriasis development is a major obstacle to successful intervention in skin pathology

We used skin biopsies from healthy donors and psoriasis patients to show the expression pattern of SLPI

We found that mice lacking SLPI had exaggerated skin changes beyond the treatment site in imiquimod-induced psoriasis

Figure 1.

Figure 2.

Figure 3.

Figure 4 SLPI prevents water loss from skin areas in a neuroreflex arc-controlled manner

Taken together, these data suggest that SLPI has a protective role in psoriasis by preventing skin dryness inherent in psoriasis pathogenesis, and that this SLPI effect is dependent on neuronal inputs operating in a reflex manner

Source: Kwiecinska P, Grygier B, Morytko A, Secretory Leukocyte Protease Inhibitor regulates nerve reflex-mediated skin barrier function in psoriasis.

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