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JEV: Adipose tissue-derived stem cell extracellular vesicles relieve osteoporosis through osteoprotegerin and miR-21-5p

 Last Update: 2021-11-03
 Source: Internet
 Author: User

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Osteoporosis is one of the most common bone diseases.

Results: EVS is rich in growth factors and cytokines related to bone metabolism and mesenchymal stem cell (MSC) migration

Figure 1 Characteristics of EVS isolated from human ASCs (ASC-EVS)

Figure 2 Administration of ASC-EVS can improve the osteoporosis phenotype of ovariectomized mice

Figure 3 The relationship between EV cytokines and bone metabolism

OPG, miR-21-5p and let-7b-5p in ASC-EVS can inhibit osteoclast differentiation and reduce the expression of bone resorption-related genes, suggesting that ASC-EVS is expected to be a cell-free therapeutic agent for the treatment of osteoporosis

Lee KS, Lee J, Kim HK,et al.

Extracellular vesicles from adipose tissue-derived stem cells alleviate osteoporosis through osteoprotegerin and miR-21-5p.

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