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    Home > Active Ingredient News > Digestive System Information > JGH: Long-term use of proton pump inhibitors increases risk of osteoporosis and hip fractures

    JGH: Long-term use of proton pump inhibitors increases risk of osteoporosis and hip fractures

    • Last Update: 2022-08-11
    • Source: Internet
    • Author: User
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    Osteoporosis is a common disease characterized by reduced bone mass and microarchitecture in patients, leading to an increased risk of osteoporotic fractur.


    Osteoporosis is a common disease characterized by reduced bone mass and microarchitecture in patients, leading to an increased risk of osteoporotic fractur.


    Infect

    This was a population-based, propensity-matched retrospective cohort study including patients ≥50 years of age who had been treated with PPIs for more than 180 da.


     

    In the Korea National Health Insurance Agency (NHIS)-CDM database, researchers found that long-term PPI users had a greater risk of osteoporosis (PPI vs non-PPI group, 242/1000 person-years vs 129/1000 person-years; HR, 62; 95% CI, 22–15; P=00


     

    The results of this study confirmed that long-term PPI was significantly associated with osteoporosis, but the results for hip fracture were inconsiste.


    The results of this study confirmed that long-term PPI was significantly associated with osteoporosis, but the results for hip fracture were inconsiste.


    Original source:

    Da Hee Pa.


    Da Hee Pa.
    Et .
    Long-term proton pump inhibitor use and risk of osteoporosis and hip fractures: a nationwide population-based and multicenter cohort study using a common data mod.
    Journal of Gastroenterology and Hepatolo.
    202 Long-term proton pump inhibitor use and risk of osteoporosis and hip fractures: a nationwide population-based and multicenter cohort study using a common data mod.
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