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Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD), which may be caused by a malfunction of the body's immune system, along with the malfunction of the intestinal flora and food antigens and genetic factors
.
The specific endoscopic features, radiological findings, and biopsy specimens of UC patients can make a specific diagnosis , but such a diagnosis is also uncertain
Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD), which may be caused by a malfunction of the body's immune system, along with the malfunction of the intestinal flora and food antigens and genetic factors
Serological markers such as myeloperoxidase (MPO) anti-neutrophil cytoplasmic antibody (ANCA) (MPO-ANCA) have been used to screen patients with ulcerative colitis (UC)
.
However, MPO-ANCA has shown limited accuracy among Asians
Screening
This study prospectively included children under the age of 17 who were evaluated at 12 Japanese pediatric centers from November 2016 to February 2018, and divided them into UC, Crohn's disease (CD), and non-IBD intestinal tract Disease group (IC) and healthy control group (HC)
.
Chemiluminescence enzyme immunoassay kit was used to analyze the levels of serum PR3-ANCA and MPO-ANCA
Figure: PR3-ANCA has higher predicted value than MPO-ANCA
This study confirmed that PR3-ANCA performs better than MPO-ANCA as a serological marker for diagnosing UC in Japanese children and adolescents
.
.
Original source:
Tatsuki Mizuochi.
Diagnostic accuracy of serum proteinase 3 antineutrophil cytoplasmic antibodies in children with ulcerative colitis.
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