echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Blood System > JHBPS: Relationship between red blood cell distribution width and blood transfusion in living donor liver transplant patients: a propensity score analysis

    JHBPS: Relationship between red blood cell distribution width and blood transfusion in living donor liver transplant patients: a propensity score analysis

    • Last Update: 2022-05-25
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    Liver transplantation (LT) is one of the most complex procedures for patients with end-stage liver disease and presents a huge challenge for surgeons and anesthesiologists
    .
    Despite efforts to find predictors of bleeding and transfusion in liver transplantation, limited information is currently available

    .
    Red blood cell distribution width (RDW), which is part of measuring changes in red blood cell size in blood samples and a standard complete blood count, has been reported in several recent studies to be associated with bleeding risk and transfusion in certain diseases and procedures

    .

    However, information on predictors of blood transfusion in living donor liver transplantation (LDLT) is limited
    .
    This study investigated the relationship between red blood cell distribution width (RDW) and intraoperative blood transfusion in LDLT recipients
    .

    This study analyzed 2546 patients who received LDLT between January 2010 and October 2019
    .
    Patients were divided into two groups according to preoperative RDW cutoff levels (<14.
    4 and ≥14.
    4)

    .
    We performed multivariate regression analysis to assess the association between RDW and intraoperative blood transfusion, and propensity score matching to compare the incidence of intraoperative blood transfusion between the two groups

    .
    The predictive power of RDW was assessed by receiver operating characteristic (ROC), integrated discrimination improvement (IDI), and net reclassification improvement (NRI) analyses

    .

    Figure 1: ROC curve of red blood cell distribution width during intraoperative blood transfusion in living donor liver transplant patients

     

    Table 1: Intraoperative Transfusion Adjusted RDW Cutoff Level (≥14.
    4)

    Table 2: The added value of evaluating RDW for predicting intraoperative blood transfusion.
    *Model 1=age+sex+BMI+DM+HTN+laparotomy history+CAD+portal vein thrombosis+ascites+MELD score+etiology+HCC+hemoglobin<12+INR >1.
    3+platelets<70k+fibrinogen<160

    .
    †Model 2=Model 1+RDW≥14.
    4

    In multivariate logistic analysis, RDW  14.
    4 was significantly associated with intraoperative blood transfusion (odds ratio [OR]: 1.
    53, 95% confidence interval [CI]: 1.
    13-2.
    06,
    P  = 0.
    005)

    .
     There was a statistically significant difference in the incidence of intraoperative blood transfusion between the two groups before matching (54.
    1% vs.
    91.
    6%,
    P  < 0.
    001) and after matching (71.
    6% vs.
    79.
    8%,
    P
    = 0.
    004) .
    RDW had predictive power for intraoperative blood transfusion (P < 0.
    001 for NRI,
    P = 0.
    035
    for IDI ) .

    Overall, the researchers found that preoperative RDW ≥14.
    4 was strongly associated with intraoperative blood transfusion in patients with LDLT

    .
    These results suggest that
    preoperative RDW may serve as a useful predictor of intraoperative blood transfusion in LDLT recipients
    .

    Liver transplantation (LT) is one of the most complex procedures for patients with end-stage liver disease and presents a huge challenge for surgeons and anesthesiologists
    .
    Despite efforts to find predictors of bleeding and transfusion in liver transplantation, limited information is currently available

    .
    Red blood cell distribution width (RDW), which is part of measuring changes in red blood cell size in blood samples and a standard complete blood count, has been reported in several recent studies to be associated with bleeding risk and transfusion in certain diseases and procedures

    .

    However, information on predictors of blood transfusion in living donor liver transplantation (LDLT) is limited
    .
    This study investigated the relationship between red blood cell distribution width (RDW) and intraoperative blood transfusion in LDLT recipients
    .

    This study investigated the relationship between red blood cell distribution width (RDW) and intraoperative blood transfusion in LDLT recipients
    .

    This study analyzed 2546 patients who received LDLT between January 2010 and October 2019
    .
    Patients were divided into two groups according to preoperative RDW cutoff levels (<14.
    4 and ≥14.
    4)

    .
    We performed multivariate regression analysis to assess the association between RDW and intraoperative blood transfusion, and propensity score matching to compare the incidence of intraoperative blood transfusion between the two groups

    .
    The predictive power of RDW was assessed by receiver operating characteristic (ROC), integrated discrimination improvement (IDI), and net reclassification improvement (NRI) analyses

    .

    Figure 1: ROC curve of red blood cell distribution width during intraoperative blood transfusion in living donor liver transplant patients

    Figure 1: ROC curve of red blood cell distribution width during intraoperative blood transfusion in living donor liver transplant patients

     

    Table 1: Intraoperative Transfusion Adjusted RDW Cutoff Level (≥14.
    4)

    Table 1: Intraoperative Transfusion Adjusted RDW Cutoff Level (≥14.
    4)
    Table 1: Intraoperative Transfusion Adjusted RDW Cutoff Level (≥14.
    4)

    Table 2: The added value of evaluating RDW for predicting intraoperative blood transfusion.
    *Model 1=age+sex+BMI+DM+HTN+laparotomy history+CAD+portal vein thrombosis+ascites+MELD score+etiology+HCC+hemoglobin<12+INR >1.
    3+platelets<70k+fibrinogen<160

    .
    †Model 2=Model 1+RDW≥14.
    4

    Table 2: The added value of evaluating RDW for predicting intraoperative blood transfusion.
    *Model 1=age+sex+BMI+DM+HTN+laparotomy history+CAD+portal vein thrombosis+ascites+MELD score+etiology+HCC+hemoglobin<12+INR >1.
    3+platelets<70k+fibrinogen<160

    .
    †Model 2=Model 1+RDW≥14.
    4

    In multivariate logistic analysis, RDW  14.
    4 was significantly associated with intraoperative blood transfusion (odds ratio [OR]: 1.
    53, 95% confidence interval [CI]: 1.
    13-2.
    06,
    P  = 0.
    005)

    .
     There was a statistically significant difference in the incidence of intraoperative blood transfusion between the two groups before matching (54.
    1% vs.
    91.
    6%,
    P  < 0.
    001) and after matching (71.
    6% vs.
    79.
    8%,
    P
    = 0.
    004) .
    RDW had predictive power for intraoperative blood transfusion (P < 0.
    001 for NRI,
    P = 0.
    035
    for IDI ) .

    P P P P <0.
    001,
    P in IDI

    Overall, the researchers found that preoperative RDW ≥14.
    4 was strongly associated with intraoperative blood transfusion in patients with LDLT

    .
    These results suggest that
    preoperative RDW may serve as a useful predictor of intraoperative blood transfusion in LDLT recipients
    .

    Preoperative RDW can be a useful predictor of intraoperative blood transfusion in LDLT recipients
    .
    Preoperative RDW can be a useful predictor of intraoperative blood transfusion in LDLT recipients
    .

     

    Original source:

    Original source:

    Sim, J.
    -H.
    , Kwon, H.
    -M.
    , Jun, I.
    -G.
    , Kim, S.
    -H.
    , Kim, B.
    , Kim, S.
    , Song, J.
    -G.
    and Hwang, G.
    -S.
    (2022), Association between red blood cell distribution width and blood transfusion in patients undergoing living donor liver transplantation: propensity score analysis.
    J Hepatobiliary Pancreat Sci.
    Accepted Author Manuscript.
    https://doi.
    org/ 10.
    1002/jhbp.
    1163.

    Sim, J.
    -H.
    , Kwon, H.
    -M.
    , Jun, I.
    -G.
    , Kim, S.
    -H.
    , Kim, B.
    , Kim, S.
    , Song, J.
    -G.
    and Hwang, G.
    -S.
    (2022), Association between red blood cell distribution width and blood transfusion in patients undergoing living donor liver transplantation: propensity score analysis.
    J Hepatobiliary Pancreat Sci.
    Accepted Author Manuscript.
    https://doi.
    org/ 10.
    1002/jhbp.
    1163.
    Sim, J.
    -H.
    , Kwon, H.
    -M.
    , Jun, I.
    -G.
    , Kim, S.
    -H.
    , Kim, B.
    , Kim, S.
    , Song, J.
    -G.
    and Hwang, G.
    -S.
    (2022), Association between red blood cell distribution width and blood transfusion in patients undergoing living donor liver transplantation: propensity score analysis.
    J Hepatobiliary Pancreat Sci.
    Accepted Author Manuscript.
    https: //doi.
    org/10.
    1002/jhbp.
    1163.


    Leave a message here
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.