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Abstract: Jia Wei/Zhao Aihua's research group from the Center for Translational Medicine, Sixth People's Hospital Affiliated to Shanghai Jiaotong University, for the first time, used a mouse model that simulates clinical bile reflux and combined cell and clinical studies to reveal that duodenogastric reflux causes gastric glycine depletion.
The increase of bile acids such as oxycholic acid and lipopolysaccharide-synthesizing bacteria increases the level of interleukin-6, activates the JAK-STAT3 signaling pathway, and eventually leads to the occurrence of cancer
.
Cryptotanshinone can effectively prevent the occurrence of bile reflux gastric cancer
.
Keywords: glycodeoxycholic acid, lipopolysaccharide, interleukin-6, bile reflux gastric cancer ,
cryptotanshinone However, large-scale epidemiological analysis at home and abroad pointed out that the eradication of Helicobacter pylori cannot completely prevent the occurrence of gastric cancer, which indicates that there are other factors besides Helicobacter pylori that induce the occurrence of gastric cancer .
Studies have reported that duodenogastric reflux is an independent risk factor for bile reflux gastric cancer, but the specific mechanism is not clear .
Jia Wei's research group from the Translational Medicine Center of the Sixth People's Hospital Affiliated to Shanghai Jiaotong University conducted a systematic study on gastric cancer caused by bile reflux .
They first studied the characteristics of bile acid profiles in the stomach of patients with clinical bile reflux gastritis and gastric cancer, and found that conjugated bile acids such as TDCA (taurodeoxycholic acid) were significantly higher than those in the control group, and the amount of bile acids in the stomach was significantly higher than that of the control group.
The microbial structure was also disturbed, and the bacteria that synthesized lipopolysaccharide (lipopolysaccharide), which was toxic to cells, increased significantly, the gastric microecological ring mirror was damaged, and the level of gastric inflammation was significantly increased .Then at the cellular level, they confirmed that TDCA and LPS elevated in the stomach due to bile reflux can promote the abnormal proliferation and cloning ability of normal gastric cells or gastric cancer cells, and make IL-6-JAK-STAT3 inflammatory/cancer signaling.
pathway activation
.
Further, they also verified in mice that TDCA, LPS, and bacteria with synthetic LPS can significantly activate inflammatory signaling pathways and induce gastritis
.
In order to more truly reflect the role of clinical bile reflux in the occurrence of gastric cancer, the research team established an animal experimental model of bile reflux in mice for the first time through gastrointestinal anastomosis, and found and verified in the model mice Based on the observed phenomenon, the activation of the inflammatory/cancer signaling pathway, the gastric mucosa of the model mice developed obvious precancerous lesions with atypia or dysplasia
.
The formation of clone formation ability of GES-1 cells under the action of TDCA and LPS The formation of AGS cell clone formation ability under the action of TDCA and LPS H&E staining of mouse gastric tissue before and after bile reflux surgery and cryptotanshinone treatment (sham: sham surgery, BR surgery: Bile reflux surgery, cryptotanshinone: cryptotanshinone, dysplasia: dysplasia, atypical hyperplasia: atypical hyperplasia) More importantly, the research team clarified the mechanism of bile reflux gastric cancer based on the above, they also studied how Prevention and treatment of gastric cancer in bile reflux gastritis
.
They found that cryptotanshinone, a diterpene quinone extracted from the traditional Chinese medicine Salvia miltiorrhiza, could effectively attenuate the occurrence of bile acid reflux gastric cancer
.
The results of this study provide new ideas for the prevention and treatment of gastric cancer in clinical bile reflux gastritis, and provide an effective target for the research and development of drugs
.
WILEY paper information: Bile Acid-Microbiome Interaction Promotes Gastric CarcinogenesisShouli Wang, Junliang Kuang, Hongwei Zhang, Wenlian Chen, Xiaojiao Zheng, Jieyi Wang, Fengjie Huang, Kun Ge, Mengci Li, Mingliang Zhao, Cynthia Rajani, Jinshui Zhu, Aihua Zhao* , Wei Jia*.
Advanced ScienceDOI: 10.
1002/advs.
202200263Click "Read the original text" in the lower left corner to view the original text of the paper
.
Introduction to AdvancedScience Journal Advanced Science is a high-quality open-source journal founded by Wiley in 2014.
It publishes innovative achievements and cutting-edge progress in various fields such as materials science, physical chemistry, biomedicine, and engineering
.
The journal is committed to maximizing the dissemination of scientific research to the public, and all articles are freely available
.
The latest impact factor is 16.
806, and the 2020 SCI journals of the Chinese Academy of Sciences are divided into the Q1 area of materials science and the Q1 area of engineering technology
.
Press and hold the QR code on the official WeChat platform of AdvancedScienceNewsWiley's scientific research information to follow us and share cutting-edge information｜Focus on scientific research trends to publish scientific research news or apply for information sharing, please contact: ASNChina@Wiley.
com
The increase of bile acids such as oxycholic acid and lipopolysaccharide-synthesizing bacteria increases the level of interleukin-6, activates the JAK-STAT3 signaling pathway, and eventually leads to the occurrence of cancer
.
Cryptotanshinone can effectively prevent the occurrence of bile reflux gastric cancer
.
Keywords: glycodeoxycholic acid, lipopolysaccharide, interleukin-6, bile reflux gastric cancer ,
cryptotanshinone However, large-scale epidemiological analysis at home and abroad pointed out that the eradication of Helicobacter pylori cannot completely prevent the occurrence of gastric cancer, which indicates that there are other factors besides Helicobacter pylori that induce the occurrence of gastric cancer .
Studies have reported that duodenogastric reflux is an independent risk factor for bile reflux gastric cancer, but the specific mechanism is not clear .
Jia Wei's research group from the Translational Medicine Center of the Sixth People's Hospital Affiliated to Shanghai Jiaotong University conducted a systematic study on gastric cancer caused by bile reflux .
They first studied the characteristics of bile acid profiles in the stomach of patients with clinical bile reflux gastritis and gastric cancer, and found that conjugated bile acids such as TDCA (taurodeoxycholic acid) were significantly higher than those in the control group, and the amount of bile acids in the stomach was significantly higher than that of the control group.
The microbial structure was also disturbed, and the bacteria that synthesized lipopolysaccharide (lipopolysaccharide), which was toxic to cells, increased significantly, the gastric microecological ring mirror was damaged, and the level of gastric inflammation was significantly increased .Then at the cellular level, they confirmed that TDCA and LPS elevated in the stomach due to bile reflux can promote the abnormal proliferation and cloning ability of normal gastric cells or gastric cancer cells, and make IL-6-JAK-STAT3 inflammatory/cancer signaling.
pathway activation
.
Further, they also verified in mice that TDCA, LPS, and bacteria with synthetic LPS can significantly activate inflammatory signaling pathways and induce gastritis
.
In order to more truly reflect the role of clinical bile reflux in the occurrence of gastric cancer, the research team established an animal experimental model of bile reflux in mice for the first time through gastrointestinal anastomosis, and found and verified in the model mice Based on the observed phenomenon, the activation of the inflammatory/cancer signaling pathway, the gastric mucosa of the model mice developed obvious precancerous lesions with atypia or dysplasia
.
The formation of clone formation ability of GES-1 cells under the action of TDCA and LPS The formation of AGS cell clone formation ability under the action of TDCA and LPS H&E staining of mouse gastric tissue before and after bile reflux surgery and cryptotanshinone treatment (sham: sham surgery, BR surgery: Bile reflux surgery, cryptotanshinone: cryptotanshinone, dysplasia: dysplasia, atypical hyperplasia: atypical hyperplasia) More importantly, the research team clarified the mechanism of bile reflux gastric cancer based on the above, they also studied how Prevention and treatment of gastric cancer in bile reflux gastritis
.
They found that cryptotanshinone, a diterpene quinone extracted from the traditional Chinese medicine Salvia miltiorrhiza, could effectively attenuate the occurrence of bile acid reflux gastric cancer
.
The results of this study provide new ideas for the prevention and treatment of gastric cancer in clinical bile reflux gastritis, and provide an effective target for the research and development of drugs
.
WILEY paper information: Bile Acid-Microbiome Interaction Promotes Gastric CarcinogenesisShouli Wang, Junliang Kuang, Hongwei Zhang, Wenlian Chen, Xiaojiao Zheng, Jieyi Wang, Fengjie Huang, Kun Ge, Mengci Li, Mingliang Zhao, Cynthia Rajani, Jinshui Zhu, Aihua Zhao* , Wei Jia*.
Advanced ScienceDOI: 10.
1002/advs.
202200263Click "Read the original text" in the lower left corner to view the original text of the paper
.
Introduction to AdvancedScience Journal Advanced Science is a high-quality open-source journal founded by Wiley in 2014.
It publishes innovative achievements and cutting-edge progress in various fields such as materials science, physical chemistry, biomedicine, and engineering
.
The journal is committed to maximizing the dissemination of scientific research to the public, and all articles are freely available
.
The latest impact factor is 16.
806, and the 2020 SCI journals of the Chinese Academy of Sciences are divided into the Q1 area of materials science and the Q1 area of engineering technology
.
Press and hold the QR code on the official WeChat platform of AdvancedScienceNewsWiley's scientific research information to follow us and share cutting-edge information｜Focus on scientific research trends to publish scientific research news or apply for information sharing, please contact: ASNChina@Wiley.
com
