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Editor’s note iNature is China’s largest academic official account.
It is jointly created by the doctoral team of Tsinghua University, Harvard University, Chinese Academy of Sciences and other units.
The iNature Talent Official Account is now launched, focusing on talent recruitment, academic progress, scientific research information, and interested parties.
Long press or scan the QR code below to follow us
.
iNature vascular disease is the main determinant of cardiovascular morbidity and mortality, including early vascular damage and subsequent cardiovascular events
.
Non-alcoholic fatty liver disease (NAFLD) is a systemic metabolic disorder that promotes the progression of vascular diseases through complex interactions
.
Although the causal relationship between NAFLD and cardiovascular disease (CVD) has not been established, more and more epidemiological studies have shown that there is an independent association between NAFLD and early vascular disease and subsequent cardiovascular events
.
In addition, mechanism studies have shown that NAFLD induces and accelerates vascular damage by increasing systemic inflammation and oxidative stress, impairing insulin sensitivity and lipid metabolism, and regulating epigenetics, intestinal flora and liver autonomic nervous system; therefore, NAFLD is the presumed driving force for the progress of CVD
.
On October 28, 2021, Wuhan University Li Hongliang, Zhe Zhigang and Huanggang Central Hospital Chen Shaoze jointly published a review titled "NAFLD as a continuous driver in the whole spectrum of vascular disease" in the Journal of Molecular and Cellular Cardiology.
The article, this review summarizes the clinical evidence supporting NAFLD's association with subclinical vascular disease and cardiovascular events, and discusses the potential mechanisms by which NAFLD promotes the progression of vascular disease
.
Vascular diseases constitute a series of vascular injuries related to genetic, behavioral and environmental risk factors, including subclinical (early) vascular diseases and subsequent vascular diseases with clinical manifestations
.
Subclinical vascular diseases are usually asymptomatic, with minor changes in vascular structure and function, including impaired vasodilation and arterial stiffness, increased intima-media thickness (IMT), and arterial calcification
.
In order to predict the risk of adverse cardiovascular events (such as ischemic heart attack and stroke), such early vascular disease damage can be detected by non-invasive or invasive methods
.
According to a global cardiovascular disease (CVD) report, by 2019, the number of deaths due to cardiovascular events is 18.
6 million
.
Therefore, early detection of vascular abnormalities and control of potential risk factors are essential to promote cardiovascular health
.
The underlying mechanism of non-alcoholic fatty liver (NAFLD) promoting the progression of vascular disease (picture from Journal of Molecular and Cellular Cardiology) Due to life>
.
NAFLD ranges from simple steatosis, non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis, and may eventually develop into hepatocellular carcinoma
.
In addition, the complications of NAFLD involve not only advanced liver disease, but also extrahepatic complications, especially CVD
.
Although there is a lack of prospective longitudinal studies to confirm the causal impact of NAFLD on the incidence of CVD, more and more clinical and basic research evidences indicate that NAFLD may be an important factor in the occurrence and progression of CVD, independent of traditional risk factors
.
In this review, the latest clinical evidence is summarized to support the direct link between NAFLD and early vascular damage and subsequent cardiovascular events, and the epidemiological link between the different pathological stages of NAFLD and vascular health is discussed.
Controversial views and suggest the main directions of future research
.
In addition, this review summarizes the potential pathophysiological links between NAFLD and vascular diseases, including recent research advances in immune inflammation, extracellular vesicles, and the autonomic nervous system
.
Reference message: https://
It is jointly created by the doctoral team of Tsinghua University, Harvard University, Chinese Academy of Sciences and other units.
The iNature Talent Official Account is now launched, focusing on talent recruitment, academic progress, scientific research information, and interested parties.
Long press or scan the QR code below to follow us
.
iNature vascular disease is the main determinant of cardiovascular morbidity and mortality, including early vascular damage and subsequent cardiovascular events
.
Non-alcoholic fatty liver disease (NAFLD) is a systemic metabolic disorder that promotes the progression of vascular diseases through complex interactions
.
Although the causal relationship between NAFLD and cardiovascular disease (CVD) has not been established, more and more epidemiological studies have shown that there is an independent association between NAFLD and early vascular disease and subsequent cardiovascular events
.
In addition, mechanism studies have shown that NAFLD induces and accelerates vascular damage by increasing systemic inflammation and oxidative stress, impairing insulin sensitivity and lipid metabolism, and regulating epigenetics, intestinal flora and liver autonomic nervous system; therefore, NAFLD is the presumed driving force for the progress of CVD
.
On October 28, 2021, Wuhan University Li Hongliang, Zhe Zhigang and Huanggang Central Hospital Chen Shaoze jointly published a review titled "NAFLD as a continuous driver in the whole spectrum of vascular disease" in the Journal of Molecular and Cellular Cardiology.
The article, this review summarizes the clinical evidence supporting NAFLD's association with subclinical vascular disease and cardiovascular events, and discusses the potential mechanisms by which NAFLD promotes the progression of vascular disease
.
Vascular diseases constitute a series of vascular injuries related to genetic, behavioral and environmental risk factors, including subclinical (early) vascular diseases and subsequent vascular diseases with clinical manifestations
.
Subclinical vascular diseases are usually asymptomatic, with minor changes in vascular structure and function, including impaired vasodilation and arterial stiffness, increased intima-media thickness (IMT), and arterial calcification
.
In order to predict the risk of adverse cardiovascular events (such as ischemic heart attack and stroke), such early vascular disease damage can be detected by non-invasive or invasive methods
.
According to a global cardiovascular disease (CVD) report, by 2019, the number of deaths due to cardiovascular events is 18.
6 million
.
Therefore, early detection of vascular abnormalities and control of potential risk factors are essential to promote cardiovascular health
.
The underlying mechanism of non-alcoholic fatty liver (NAFLD) promoting the progression of vascular disease (picture from Journal of Molecular and Cellular Cardiology) Due to life>
.
NAFLD ranges from simple steatosis, non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis, and may eventually develop into hepatocellular carcinoma
.
In addition, the complications of NAFLD involve not only advanced liver disease, but also extrahepatic complications, especially CVD
.
Although there is a lack of prospective longitudinal studies to confirm the causal impact of NAFLD on the incidence of CVD, more and more clinical and basic research evidences indicate that NAFLD may be an important factor in the occurrence and progression of CVD, independent of traditional risk factors
.
In this review, the latest clinical evidence is summarized to support the direct link between NAFLD and early vascular damage and subsequent cardiovascular events, and the epidemiological link between the different pathological stages of NAFLD and vascular health is discussed.
Controversial views and suggest the main directions of future research
.
In addition, this review summarizes the potential pathophysiological links between NAFLD and vascular diseases, including recent research advances in immune inflammation, extracellular vesicles, and the autonomic nervous system
.
Reference message: https://
