JPR: Analysis of the metabolic properties of the body in PATIENT COVID-19 patients may reveal its multi-organ effects.

September 14, 2020 // -- SARS-CoV-2, which induces COVID-19, causes a range of body symptoms, including respiratory stress, multiple organ failure and even death, and the virus mainly targets the lungs, but many patients also develop symptoms of the non-respiratory system; In the study, published in the international journal Journal of Proteome Research, scientists from The University of Modok and others compared levels of lipoproteins and metabolites in the blood of patients with COVID-19 and healthy individuals, revealing signs of multiple organ damage in patients, or promising to help diagnose and treat COVID-19 patients later.
Photo Source: NIAID's current diagnosis of COVID-19 relies heavily on the detection of viral RNA and the body's resistance to viral antibodies, both of which are prone to false negative results and other limitations; 2 The method of infection mainly includes analyzing metabolic changes in the body in the later stages of viral infection, in which the researchers wanted to analyze the systemic systemic effects of COVID-19 on patients and determine whether there were general metabolic characteristics of COVID-19 infection.
researchers studied 17 patients who tested positive for COVID-19 using current methods, 25 healthy control individuals with age, gender and BMI matching them (COVID-19 test results were negative), and then analyzed blood samples from participants' bodies, and then measured the levels of lipoproteins, metabolites, and amino acids in these blood samples using MRI spectroscopy and liquid chromatography-mass spectrometry.
By using multivariate statistical analysis to detect differences between patients and control individuals, the researchers found metabolic characteristics of SARS-CoV-2 infections, including acute inflammation, liver damage, diabetes and cardiovascular disease risk, and are now looking at larger patients In addition to using metabolite-based diagnostic testing techniques developed, the researchers said, the results suggest that COVID-19 rehabilitation should be evaluated to determine whether their risk of other diseases increases.
() Original source: Ruey Leng Loo, Samantha Lodge, Torben Kimhofer, et al. Quantitative In-Vitro Diagnostic NMR Spectroscopy for Lipoprotein and Metabolite Measurements in Plasma and Serum: Recommendations for Analytic Artefact Basication with Special Reference to COVID-19/SARS-CoV-2 Samples, Journal of Proteome Research (2020). DOI: 10.1021/acs.jproteome.0c00537.