Lancet: Effects of postoperative radiotherapy strategies on PSA processes for prostate cancer

The best time for postoperative radiotherapy for prostate cancer is uncertain.
researchers recently compared the effects of complementary radiotherapy and rescuing radiotherapy on the biogenic process of prostate-specific antigens (PSA) in patients.
RADICALS-RT study, patients with at least one biochemical progression risk factor (pathological stage 3 or 4, Gleason scored 7-10, positive edge, or preoperative PSA ≥10 ng/mL) after a root-and-treated prostatectomy were recruited.
patients were randomly treated with assisted radiotherapy or saved radiotherapy strategies (PSA≥0.1 ng/mL or three consecutive elevateds based on PSA biopic progress.
factors included Gleason scores, edge states, and radiotherapy options (52.5 Gy, 20 or 66Gy, 33 times).
observational indicators were no far-end metastasis, and results were reported on bio-chemical progression-free survival rates, hormone-free therapy, safety and patient reporting.
1,396 patients participated in the study, 699 (50%) received resuscitation radiotherapy and 697 (50%) received assisted radiotherapy.
of patients with the disease was 65 years, and the medium follow-up time was 4.9 years.
649 (93%) of the 697 participants in the
auxiliary radiotherapy group received treatment within six months, and 228 (33%) of the 699 participants in the rescue radiotherapy group received radiotherapy within eight years of the random group.
85 per cent and 88 per cent (HR: 1.10) were 85 per cent and 88 per cent, respectively, in the secondary assisted radiotherapy group and in the rescue radiotherapy group.
93% of the assisted radiotherapy group did not require unused hormone therapy after 5 years, compared with 92% of the rescue radiotherapy group (HR:0.88).
self-described urinary incontinence was more severe when patients in the auxiliary radiotherapy group were 1 year old (average score 4.8 vs. 4.0).
6 percent of individuals in the assisted radiotherapy group reported 3-4 levels of urethra stenosis within 2 years, while 4 percent in the rescue radiotherapy group.
results do not support routine auxiliary radiation therapy after prostate root therapy, which increases the risk of urinary system disease.
observation strategy of saving radiotherapy according to PSA biochemic progress should be the first line of treatment after prostatectomy.