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Lancet Gastroenterol Hepatol: Efficacy analysis of 40 kinds of freeze-dried oral capsules of fecal bacteria in the treatment of recurrent Clostridium difficile infection

 Last Update: 2021-03-17
 Source: Internet
 Author: User

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Fecal microbiota transplantation (FMT) is very effective against repeated infections of Clostridium difficile , but it has inherent risks.

This is an open-label, single-group feasibility phase 1 study conducted in Canada, recruiting patients with mild to moderate C.

From September 19, 2018 to February 28, 2020, a total of 19 adult patients (median age 65 years; 12 females, 7 males) who had at least two C.

Within 40 days of initial treatment, 15 of the 19 patients (79%) did not recur with C.

After MET-2 treatment, the patient's life treatment was significantly improved, and the alpha diversity in the fecal microbial composition was also significantly improved.

In conclusion, MET-2 has shown good safety, tolerability and effectiveness for patients with recurrent Clostridium difficile infection.

Original source:

Dina Kao, et al.

The effect of a microbial ecosystem therapeutic ( MET-2) on recurrent Clostridioides difficile infection: a phase 1, open-label, single-group trial in this message

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