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Leukemia: Identification of biomarkers related to endothelial dysfunction and thromboembolism in acute lymphoblastic leukemia

 Last Update: 2021-09-12
 Source: Internet
 Author: User

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Past studies have shown that after adopting the best treatment strategies, the five-year overall survival rates of childhood and adolescent acute lymphoblastic leukemia (ALL) exceed 90% and 75%, respectively

The five-year overall survival rates of childhood and adolescent acute lymphoblastic leukemia (ALL) exceed 90% and 75%, respectively

TE mainly originates from veins and is one of the most common and serious toxic reactions.

diagnosis

Previous studies have found that endothelial dysfunction (ED) plays a vital role in thrombosis

Endothelial dysfunction (ED) plays a vital role in thrombosis

Research flow chart

In this retrospective study, the researchers aimed to analyze the above three biomarkers (TM, Sdc-1, VEGFR-1) in prospectively collected blood samples and 55 cases and 165 cases treated under the NOPHO ALL 2008 regimen.

The researchers aimed to analyze the three biomarkers (TM, Sdc-1, VEGFR-1) in prospectively collected blood samples and 55 cases and 165 time-matched controls treated under the NOPHO ALL 2008 regimen for thromboembolism The correlation between risks

Individual sample measurement of endothelial biomarkers

In an adjusted analysis of age, gender, and risk group, the researchers found that increased levels of TM and VEGFR-1 were independently associated with an increase in the incidence of thromboembolism

Increased levels of TM and VEGFR-1 are independently associated with an increase in the incidence of thromboembolism

Endothelial dysfunction and thromboembolism in children, adolescents, and young adults with acute lymphoblastic leukemia.

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