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Langerhans cell histiocytosis (LCH), a clonal histiocytic tumor, is a rare, heterogeneous histiocytic disorder that occurs in patients of all ages with a variety of clinical manifestations and heterogeneity Prognosis
.
There are no standard therapies available for patients with relapsed/refractory LCH
Langerhans cell histiocytosis (LCH), a clonal histiocytic tumor, is a rare, heterogeneous histiocytic disorder that occurs in patients of all ages with a variety of clinical manifestations and heterogeneity Prognosis
This single-center, single-arm, phase 2 study enrolled 32 patients diagnosed with relapsed/refractory LCH
Figure 1: Response of 32 patients with relapsed/refractory LCH to TCD regimen
Figure 1: Response of 32 patients with relapsed/refractory LCH to TCD regimenThe primary endpoint was event-free survival (EFS)
.
An event was defined as progression or death from any cause during or after TCD treatment
The primary endpoint was event-free survival (EFS)
Figure 2: Survival of R/R Langerhans cell histiocytosis
.
An event-free survival rate valid for the entire cohort
Figure 2: Survival of R/R Langerhans cell histiocytosis
The overall remission rate was 87.
Common toxicities with the TCD regimen included grade 1-2 neutropenia (18.
This study has several limitations
Original source:
Original source:Wang, Jn.
Wang, Jn.
, Liu, T.
, Zhao, Al.
et al.
Phase 2 study of oral thalidomide-cyclophosphamide-dexamethasone for recurrent/refractory adult Langerhans cell histiocytosis.
Leukemia (2022).
https://doi.
org/10.
1038 /s41375-022-01555-8.
et al.
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