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Leukemia: Preclinical evaluation of eltrombopag in the PDX model of myelodysplastic syndrome

 Last Update: 2021-08-01
 Source: Internet
 Author: User

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Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disease characterized by bone marrow (BM) dysplasia, reduction of blood cells, recurrent genomic aberrations, and the susceptibility of the disease to develop into acute myeloid leukemia

Although the current research on the molecular characterization of MDS has made great progress, the lack of preclinical models to solve functional problems has also made it difficult to convert the discovered mutation data into new treatment strategies

In this study, the researchers mainly analyzed the effectiveness and safety of the thrombopoietin receptor agonist eltrombopag (Eltrombopag)

Researchers mainly analyzed the effectiveness and safety of the thrombopoietin receptor agonist eltrombopag

Preclinical evaluation using xenograft models derived from MDS patients

All in all, the results of the study reveal that the MDS PDX model can be used as a potential tool for testing new treatment concepts in MDS preclinical trials

The MDS PDX model can be used as a potential tool for testing new treatment concepts in MDS preclinical trials

Preclinical evaluation of eltrombopag in a PDX model of myelodysplastic syndromes.

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