Leukemia: The expression pattern and prognostic potential of circular RNA in mantle cell lymphoma

Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin's lymphoma and belongs to B-cell lymphoma
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Previous studies have shown that the introduction of a chemical containing cytarabine immune autologous therapy after stem cell transplantation (ASCT) can significantly improve the prognosis of patients with MCL

Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin's lymphoma and belongs to B-cell lymphoma

Mantle cell lymphoma is characterized by significant differences in patient outcomes, so there is an urgent need for powerful prognostic biomarkers to identify the prognostic status of patients
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Circular RNA (circRNA) is a new type of abundant endogenous non-coding RNA, which has tissue and disease-specific expression patterns
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These molecules are formed through an atypical splicing mechanism, which is called reverse splicing, which connects the 3'end of an exon to the 5'end of the same or upstream exon to form a loop

Although the expression of circRNA is usually lower than its linear counterpart, due to the high stability of circRNA, its half-life is longer than that of mRNA, so circRNA can be used as a potential prognostic biomarker for various diseases including cancer
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This study aims to explore the correlation between the expression pattern of circRNA in MCL and the prognosis
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The researchers analyzed the expression of circRNA through RNA sequencing, and used NanoString nCounter Analysis to explore the prognostic potential of 40 highly expressed circRNAs in the Nordic MCL2 and MCL3 clinical trial samples

CircRNA is widely expressed in MCL

CircRNA is widely expressed in MCL

Researchers report the circSCORE scoring system based on circRNA features developed in the training cohort MCL2, which can highly predict the time to disease progression (TTP) and lymphoma-specific survival rate (LSS)
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Researchers report the circSCORE scoring system based on circRNA features developed in the training cohort MCL2, which can highly predict the time to disease progression (TTP) and lymphoma-specific survival rate (LSS)
.

Researchers report the circSCORE scoring system based on circRNA features developed in the training cohort MCL2, which can highly predict the time to disease progression (TTP) and lymphoma-specific survival rate (LSS)

The CircSCORE score is significantly correlated with the patient’s prognosis

The CircSCORE score is significantly correlated with the patient’s prognosis

All in all, the results of the study revealed that circRNA is a promising potential prognostic biomarker in MCL, and the circSCORE score can improve the identification of high-risk patients
.

The results of the study revealed that circRNA is a promising potential prognostic biomarker in MCL, and the circSCORE score can improve the identification of high-risk patients
.

The results of the study revealed that circRNA is a promising potential prognostic biomarker in MCL, and the circSCORE score can improve the identification of high-risk patients

Expression patterns and prognostic potential of circular RNAs in mantle cell lymphoma: a study of younger patients from the MCL2 and MCL3 clinical trials.

 

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