Link between vascular inflammation and mitochondrial fission abnormalities

May 11, 2020 /PRNewswire/--- most cells in the human body contain tiny "power plants" called mitochondria that generate a lot of energy for daily activitiesLike dynamic renewables, these small power plants are constantly splitting and gatheringThe balance between fission and fusion is essential for health, especially cardiovascular healthin a new study, scientists at Temple University School of Medicine have discovered a new mechanism through which abnormal mitochondrial fission in endothelial cells ( cells located on the inner surface of blood vessels ) can lead to inflammation and oxidative stress in the cardiovascular systemThey further demonstrated that salicylic acid can maintain the balance of mitochondrial fission fusion, thereby reducing inflammationSalicylic acid is the main active ingredient in daily pain-relieving drugs such as aspirin(photo source:the groundbreaking study was published online May 11 in The Journal of Highonnormally, the dynamic protein-related protein 1 (Drp1) plays a beneficial role in maintaining endothelial cell fission fusion balanceHowever, when inflammation puts pressure on cells, it increases fission activity, leading to the crushing of mitochondria, leading to chronic inflammationDr Eguchi said: "It is not clear how Drp1 promotes the fragmentation of mitochondria during the inflamed of the epithelial cellsWe wanted to know if it might interact with NF-B, which is involved in inflammatory responses and endothelial dysfunction"
in this study, DrEguchi and his colleagues stimulated the inflammatory response of endothelial cells and mitochondrial fragmentationThey then studied the effects of blocking Drp1 activity and expressionThese experiments show that inhibiting Drp1 activity in cells inhibits mitochondrial fragmentation, NF-B activation and inflammatory response In the cells where the activity of NF-B inhibited, and in mouse models where Drp1 expression was inhibited, the authors observed a decrease in mitochondrial fragmentation and an inflammatory response the next, researchers found that the anti-inflammatory drug salicylic acid also reduces the fragmentation of mitochondria Salicylic acid acts as anti-inflammatory by blocking the activity of a variety of inflammatory molecules, including NF-B In mice, salicylic acid therapy reduced inflammation and mitochondrial fragmentation through its effecton on NF-B and downstream pathways dr Eguchi said: "Our findings suggest that salicylic acid may be able to maintain a balance between mitochondrial fission and fusion under inflammatory conditions Since salicylic acid has been used in aspirin and related painkillers, the observations may have a clinical lyability effect "
future work, Dr Eguchi plans to explore the effects of aging and other factors on Drp1 and mitochondrial fragmentation in endothelial cells (biovalleybioon.com) Source: Linkfoundblood blood vessel and ampinmitochindalfision