Master of Immunization: Academician Dong Chen's high-level review

Foreword Immugent has systematically introduced all the research papers of Academician Dong Chen up to now in his tweet - Master of Immunity: Academician Dong Chen's full summary of research resul.
However, through literature search, the editor found that Academician Dong Chen not only published many high-level research papers, but also published many very influential review articl.
So today, the editor will continue to interpret .
Dong Chen so f.
Some representative reviews publish.
Through the last tweet, the editor introduced .
Dong Chen's mentor, and as the discoverer of B cells, Max.
Cooper, is one of the founders of modern immunology, and found that .
Dong Chen's current h-index is already very hi.
Approaching his ment.
In fact, Max.
Cooper is now in his 70s, and it will be difficult to make original breakthroughs in scientific research in the futu.
Academician Dong Chen is only in his 50s, and he is likely to surpass his mentor in the futu.
The main reason why .
Dong Chen can stand out in the immunology field of the big boss is that he has published a series of influential revie.
The following editor selects some of the reviews of .
Dong Chen for interpretati.

The picture comes from the Intern.

Since the review published by .

Dong Chen covers multiple fields of immunology, the editor will select representative works from the direction of Th development and differentiation, the direction of immune disease and the direction of system immunology for interpretati.

The direction of Th development and differentiation Regarding the research status of .

Dong Chen in the field of Th cell differentiation and development, I don’t need to say more he.

Among the five types of Th cells that are relatively certain at present, Academician Dong Chen’s team found two (Th17 and Tfh), and then .

Dong Chen wrote a review in this direction just like summarizing his existing work, and generally scholars send reviews to journals with the highest impact factor, while Dong Chen’s review is completely It is to look at the mood and the manuscript of the editorial department of the magazi.

This is the difference between the scientific research civilians and the bigwi.
For the research direction of Th differentiation and development, the first thing to introduce is .

Dong Chen's review on the differentiation and development of Th1An earlier one was published in Nat Rev Immunol in 2006, entitled: Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cel.

Th1 and Th2 cells perform different roles in the immune system and have long been considered two sides of the adaptive immune respon.

However, in this review, the authors propose that Th17 cells differ from Th1 and Th2 cells based on a series of studies, so this concept may need to be redefin.

In particular, recent data suggest that interleukin-17 (IL-17) is produced by Th17 cells, which is distinct from traditional Th1 and Th2 cell subse.

Furthermore, the production of these IL-17-producing CD4+ T cells is independent of cytokines and transcription factors that mediate Th1 and Th2 cell development during the immune respon.

In some animal models of autoimmunity, IL-17 plays a crucial role in regulating tissue inflammation and disease development, therefore, the authors suggest that IL-17-produced CD4+ T cells represent a distinct lineage of inflammatory Th cel.

There are many reviews on Th17 cell differentiation by Dong Ch.

One of the most influential reviews was published in Nat Rev Immunol in 2008, entitled: TH17 cells in development: an updated view of their Article on molecular identity and genetic programmi.
After activation, CD4+ T cells can differentiate into different helper T cells (Th), and different Th cells have different developmental regulatory pathways and biological functio.

In recent years, Th17 cells have been recognized as a new type of effector Th cells, which play an important role in the immune response to infectious agents and various immune diseas.

In the past two or three years, the immunological community has made rapid progress in the understanding of the differentiation process of Th17 cel.

In this review, the authors systematically summarize current knowledge on the unique gene expression, cytokine-mediated regulation, and transcriptional programming of Th17 cells and provide personal perspectives on lineages that need to be elucidated in greater detail in the futu.

After talking about the differentiation and development of Th17 cells, we will introduce another major research direction of .

Dong Chen: the differentiation and development of Tfh cel.

When it comes to a review of Tfh differentiation and development, we have to mention this article published in the journal Immunol Rev in 2013, with the title: Transcriptional regulation of follicular T-helper (Tfh) cel.

Follicular helper T cells (Tfh) are a new subset of effector CD4+ T cells whose main function is to specifically assist in the differentiation and development of B cells in the germinal center respon.

The gene expression profile of Tfh cells differs from other established CD4+ T cell lineages, such as Th1, Th2, Th17 and regulatory T cells (Tre.

Tfh cell differentiation is caused by a major transcription factor Bcl6 and a transcriptional regulatory network of IRF4, c-Maf, Batf and STAT3/
During Tfh cell development, increased CXCR5 expression guides the migration of activated T cells toward the follicle, and interaction with B cells leads to the upregulation of Bcl6, which helps Tfh cells establish effector and memory progra.

This review systematically summarizes recent advances in the molecular mechanisms of Tfh differentiation and discusses future prospects for this important research ar.

There are many reviews on the differentiation and development of other Th cells by .

Dong Chen, so I will not interpret them one by one he.

There are related article information at the end of this artic.

The basic research of immunology in the direction of immune diseases is, in the final analysis, a wedding dress for immune-related diseas.

Therefore, any basic research article in immunology is more meaningful if it is linked to a specific immune disea.

Among them, Th17 cells are more meaningf.

It is mainly related to the pathogenesis of various autoimmune diseases of the bo.

There are also many reviews of different immune diseases by .

Dong Ch.

In the following section, the editor lists some representative reviews for interpretati.

Arthritis is a common disease that can seriously affect normal life, especially for elderly patients with arthrit.

In severe cases, they will lose the ability to walk upright; and not only occurs in the elderly, the incidence of juvenile arthritis in recent years has also increas.

increasing year by ye.

There are many reasons for arthritis, but in the final analysis, it is caused by the dysfunction of the body's immune syst.

As early as 2003, .

Dong Chen published an article titled: Inducible costimulator is essential for collagen-induced arthritis in the journal J Clin Invest, which explained one of the important types of arthritis for us, that is, collagen-induced join.

cause of inflammati.
Tumor immunity-related research has been active in people's field of vision since it was awarded the Nobel Prize in Medicine in 201 Although tumor immunity is not one of the main research directions of Dong Chen's team, his team still has a lot of tumor immunity-related resear.

High-level articles publish.

The article titled: New checkpoints in cancer immunotherapy published in Immunol Rev in 2007 introduced us to another important aspect of tumor immune checkpoints - the importance of B7 family molecul.

The immune response must be appropriately tuned to effectively eliminate invading pathogens while maintaining tolerance to self-antige.

T cells are the main effector cells that fight tumor growth and kill tumor cells, and have always been the focus of research on tumor immuni.

Immune checkpoints play critical roles in T cell activation and determine the functional outcome of T cell receptor (TCR) signali.

Blockade of the immune checkpoints CTLA-4 and PD-1 has been one of the most successful cancer immunotherapi.

In this review, the authors focus on 3 novel inhibitory checkpoint molecules of the B7 family, B7-h3, B7S1 and VIS.

This article reviews its expression in tumors and its role in controlling and suppressing T cell immune responses and anti-tumor immuni.

These pathways deserve to be investigated in future cancer immunothera.

Autoimmune diseases and tumors are two different directions in terms of pathogenes.

The former is the abnormal activation of the immune system function, while the latter is the inhibition of the anti-tumor immune function, but it is precisely in this way that there are two seemingly opposite diseas.

subtle connecti.
Dong Chen’s article titled: IL-9-producing T cells: potential players in allergy and cancer published in Nat Rev Immunol in 2021 explained the relationship between these two diseases from the perspective of IL- conta.

The body's IL-9-producing CD4+ T cells are considered to be a distinct subset of T helper cells (Th9) due to their unique developmental programs in vitro and the expression of unique transcription factors, including .

Whether these cells represent a truly unique subset of Th cells in vivo is still debated, but they are closely related to T helper 2 (Th2) cells detected in allergic disea.

In recent years, there has been increasing evidence that IL-9-producing T cells may be effective in eradicating advanced tumors, especially with a strong ability to inhibit the growth of melano.

In this review, the authors review recent research reports on the development of IL-9-producing T cells and their function in disease settings, with a particular focus on allergic diseases and canc.

In addition, the article discusses recent studies on the therapeutic targets of these cells in patients with chronic allergic disease, and their potential use in cancer immunothera.

System Immunology .

Dong Chen’s earliest review on immune system research was published in the journal An.

R.

Immunol in 2002, titled “MAP kinases in the immune response”, and he must have done any immune cell mechanism The research partners all know about MA.

This pathway is one of the most important functional pathways of immune cel.

This review by .

Dong Chen is also one of the classic reviews of immune system resear.

So far, this review has been cited nearly 2,000 tim.
MAP kinases are one of the oldest signal transduction pathways and have been widely used in many physiological processes during evoluti.

In mammals, MAP kinases are involved in all aspects of the immune response, from the initiation of innate immunity, to the activation of adaptive immunity, to cell death when immune function is comple.

In this review, the authors systematically summarize recent advances in understanding the function and regulation of MAP kinases during these phases of the immune respon.

Another important review by .

Dong Chen in the direction of systemic immunology was published in the journal J Exp Med in 2006, entitled "New battlefields for costimulatio.

The functional mechanism of immune cel.

Costimulation modulates the activation signal of naive T cells when they first encounter antigen in secondary lymphoid orga.

But the recently discovered co-stimulatory molecules of the B7 family appear to have other roles beyond initial T-cell activati.

Emerging evidence suggests that negative co-stimulatory factors expressed by tumor and normal tissues are locally protective against T cell-mediated atta.

Of course, T cells are mainly receivers of costimulatory signals, and the senders of costimulatory signals include many other types of immune cells, including some stromal cel.

The important role of cytokines in the immune system must not be repeat.

As one of the main ways for immune cells to function, the secretion and regulation mechanism of cytokines has always been an important research direction in system immunolo.

Just last year, Dong Chen's team published an important review in the journal Annual Review of Immunology with an article entitled "Cytokine Regulation and Function in T Cell.
T lymphocytes are the main effector cells of cellular immunity, producing cytokines in the immune response to mediate inflammation and regulate other types of immune cel.

In studies over the past 30 years, CD4+ T cells exhibit marked heterogeneity in cytokine expression, leading to the discovery of T helper 1 (Th1), Th2, Th17 and T follicular helper T cell subse.

These cells have unique developmental and regulatory pathways and play unique roles in immunity and immune-mediated patholo.

Other types of T cells, including regulatory T cells and γδ T cells, as well as innate lymphocytes, show similar subset characteristics, which may play different roles in immuni.

There are mechanisms that prevent T cells from producing cytokines to maintain immune tolerance to self-antigens, some of which may also underline immune exhaustion in the tumor conte.

An in-depth understanding of the regulatory mechanism and function of cytokines will provide new thinking for the treatment of many human diseas.

In the end, for many of us newcomers who have just entered the scientific research industry, they will think that publishing a review is much simpler than a research paper, but this is not the ca.

The editor himself has tried to write some reviews, but most of them ended in failu.

The reason is that the reviews written by himself are piles of literature, and he can't read th.

And a high-quality review has a huge and lasting influence in the field, so many of the highly cited articles you see are revie.

The review written by .

Dong Chen is worth readi.

After all, .

Dong comes from a famous family, and coupled with decades of scientific research accumulation, .

Dong Chen has a very comprehensive grasp of immunolo.

Especially for those who study classic immune cell differentiation and development and autoimmune diseases, you must read a few more reviews by .

Dong Chen
Well, in this tweet, the editor mainly interprets some representative reviews published by .

Dong Ch.

In addition, the other review editors published by .

Dong Chen are summarized at the end of the artic.

You can select the reviews you are interested in and re.

Finally, if you have other domestic scientific research experts you want to know about, you can comment below, and Shengxin people will selectively select representatives from different research fields, and then publish relevant tweets for interpretati.
[Summary of review papers] 2002 Transcriptional regulation of th2 differentiation by inducible costimulat.

2002 MAP kinases in the immune respon.

2003 B7S1, a novel B7 family member that negatively regulates T cell activation2005 MAP kinases in immune respons.

2006 Diversification of T-helper -cell lineages: finding the family root of IL-17-producing cel.

2006 New battlefields for costimulati.

2007 Inhibitory costimulation and anti-tumor immuni.

2008 Regulation and pro-inflammatory function of interleukin-17 family cytokin.

2008 Regulatory mechanisms of helper T cell differentiation: new lessons learned from interleukin 17 family cytokin.

2008 TH17 cells in development: an updated view of their molecular identity and genetic programmi.

2008 Keeping autoimmunity in check: how to control a Th17 cell controll.

2009 Yin-Yang of costimulation :crucial controls of immune tolerance and functi.

2010 Helper T-cell heterogeneity: a complex developmental issue in the immune syst.

2011 Molecular mechanisms of T-cell toleran.

2011 Highlights of 10 years of immunology in Nature Reviews Immunolo.

2013 Transcriptional regulation of follicular T-helper (Tfh) cel.

2013 Toll-like receptor regulation of effector T lymphocyte functi.

2013 A complex issue on CD4(+) T-cell subse.

2013 New territory for T follicular helper cel.

2013 The CD70-CD27 axis, a new brake in the T helper 17 cell respon.

2014 Targeting Th17 cells in immune diseas.

2015 Interleukin-17A deficiency ameliorates streptozotocin-induced diabetes2017 New B7 Family Checkpoints in Human Cancers2017 IL-25 in allergic inflammati.

2017 New checkpoints in cancer immunothera.

2020 Seventeen on inflammati.

2021 Defining the TH17 cell linea.

2021 IL-9-producing T cells: potential players in allergy and canc.

2021 Cytokine Regulation and Function in T Cel.

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