Metabolism: Relationship between muscle area and density and risk of all-cause dying.

!---- Muscles play a key role in body function and metabolismHowever, little is known about the association between muscle and mortalityRecently, a study published in the journal Metabolism-Clinical and The Aarne, an authoritative journal for metabolic diseases, looked at the association between the number (area) and mass (density) of abs and the risk of all-cause mortality in different populations without cardiovascular diseaseThe data came from a sub-study of abdominal body composition, inflammation, and cardiovascular disease in the multi-ethnic atherosclerosis prospective cohort studyThe participants were adults (45-85 years old) without cardiovascular disease, including Hispanics, African-Americans, Chinese or whiteOf the initial 6,814 MESA participants, a randomly representative sample (n-1974) participated in the study of body compositionAbdominal muscle area and density are measured by a computer tomography across L2-L4Muscle density is measured by the decay of Hounsfield units and in area in cm2The Cox Proportional Risk Model for Gender Stratification assessed the risk of all-cause dying in a specific gender-specific quarter of muscle area and adjusted the mixed factorsAt the baseline, the average ages of men (n-946) and women (n-955) were 61.5 years and 62.5 6 years, respectively, with median follow-up times of 10.6 years and 10.9 years, respectivelyMuscle density is inversely proportional to mortalityWhen the risk factors for death, lifestyle, BMI and visceral fat were adjusted, the risk of men with the highest quadriceps decreased by 73% compared to the lowest quartile (HR-0.27, 95% CI-0.14-0.51; trend p-lt-0.001), and women decreased by 57% (HR-0.43, 95% CI-0.18-1.01;trend-of-0.044-of-a-the-point-of-0-trend-of-the-population)There was no association between muscle area in men (trend p-0.58) or women (trend p-0.47) and total-cause mortalityOver a 10-year follow-up, higher abdominal muscle density, rather than muscle area, significantly reduced the risk of all-cause mortalityIn community residents, muscle mass can be a strong predictor of mortality