-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
February 22, 2021 // --Recently, in a research report published in the international journal Molecular Cancer , scientists from Vienna Medical University and other institutions have identified an inflammatory signaling molecule and a Previously unknown molecular associations between major oncogenes.
Molecular Cancer
Researcher Johannes A.
Image source: Medical University of Vienna
The researchers said that inflammatory enzymes can adsorb phosphates at special sites of c-Myc protein, thereby inducing slow degradation of molecules and subsequent accumulation in cells, leading to higher activity; containing can mimic phosphorylation The main characteristics of c-Myc mutant cells are higher cell division rate and greater resistance to chemotherapy.
In the article, the researchers used a mouse model of prostate cancer to confirm the interaction between the two proteins.
Original source:
Original source:Moser, B.
Moser, B.
, Hochreiter, B.
, Basílio, J.
et al.
biomedcentral.
com/articles/10.
1186/s12943-021-01308-8">The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity .
Mol Cancer 20, 16 (2021).
doi: 10.
1186/s12943-021-01308 -8 biomedcentral.
com/articles/10.
1186/s12943-021-01308-8">The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity Mol Cancer
