Mol Cell: Uncovering the special gene network of leukemia factors

February 9, 2021 // -- In a recent study published in the international journal Molecular Cell entitled "Definition of a small core codeical circuited by AML1-ETO", scientists from Vanderburg University and other institutions revealed a particular genetic network of leukemia factors.
researchers say transcription factors are a special protein that regulates gene expression, play a key role in cell fate decision-making, and are frequent targets for multiple human cancer mutations, and understanding the molecular mechanisms of transcription factor-induced disease requires researchers to identify direct genetic targets, but traditional methods are often time-consuming and difficult to distinguish between direct and secondary changes.
picture source: Molecular Cell (2020). 'In this study, we designed a chemical genetic method that can shorten the analysis of transcription factors from the last few days to a few minutes,' said Dr. Kristy Stengel, a researcher at DOI:10.1016/j.molcel.2020.12.005.
researchers applied this new method to the fusion of the protein AML1-ETO, the most frequent chromosomal susceptible manifestation of acute myeloid leukemia.
the researchers also defined a small core network of about 60 direct AML1-ETO regulatory genes, including myelin differentiation and cell fate-determining mediats.
the results of this paper show that the inhibition of the protein AML1-ETO fusion in this small network can damage myelin differentiation, and related research may help scientists develop new therapeutic strategies to treat a variety of diseases, including leukemia, in the future.
() Original source: Kristy R. Stengel, Jacob D. Ellis, Clare L. Spielman, et al. Definition of a small core transcriptional circuit regulated by AML1-ETO, Molecular Cell (2020). DOI: 10.1016/j.molcel.2020.12.005