Nat Aging: Large-scale plasma proteome analysis to identify risk proteins related to dementia

Existing studies have shown that the blood levels of several biologically-related molecules are related to the risk of Alzheimer’s disease and wider dementia, but at present, we still lack information about all changes in the plasma proteome in the previous years of dementia.

In addition, so far, plasma proteomics studies on dementia are almost cross-sectional, and may be affected by reverse causality.

Gene expression studies have identified transcriptional changes consistent with dementia.

Recently, high-throughput techniques for characterizing the human proteome have made progress, enabling the simultaneous evaluation of approximately 5000 circulating proteins.

The whole proteome is associated with the occurrence of dementia

Mendel random samples using two methods, the researchers found that two kinds of dementia-related protein (SVEP1 and vascular angiotensin) and Alzheimer's disease there is a causal relationship .

In addition, the path analysis of a wider range of dementia-related proteins shows that immune, lipid, metabolic signals and hemostatic pathways are related to the pathogenesis of dementia .

Original source:

Keenan A.