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TP53 is the most commonly mutated gene in cancer
TP53 is the most commonly mutated gene in cancer
Chemotherapy is the standard treatment strategy for childhood acute lymphoblastic leukemia (ALL), but patients sometimes experience recurrence of the disease and the development of drug resistance
Children in childhood ALL, TP53 mutation in the diagnosis of rare time, but enrichment at relapse and independently predict adverse outcomes in patients
In this study, the researchers revealed a specific mechanism by which chemotherapy-induced drug resistance-related mutations lead to disease recurrence
Researchers have revealed a specific mechanism by which chemotherapy-induced resistance-related mutations lead to disease recurrence
TP53 mutations in recurrent ALL
TP53 mutations in recurrent ALLClonal evolution analysis revealed continuous MMR inactivation and TP53 mutations in some ALL patients
Synergistically induced TP53 mutation acquisition model
Synergistically induced TP53 mutation acquisition modelAll in all, the results of the study revealed that the TP53 R248Q mutation in recurrent ALL originated from the synergistic effect of thiopurine therapy and MMR deficiency, and proposed strategies to prevent or treat disease recurrence caused by TP53 mutations
The TP53 R248Q mutation in recurrent ALL originates from the synergistic effect of thiopurine therapy and MMR deficiency, and proposes strategies to prevent or treat disease recurrence caused by TP53 mutation
Chemotherapy and mismatch repair deficiency cooperate to fuel TP53 mutagenesis and ALL relapse.
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