Nat Cell Biol: What's new! Cells with lower "stickiness" may be more prone to cancer!

10, 2020 // -- In a recent study published in the international journal Nature Cell Biology, scientists from the University of Leipzig and others analyzed in detail the structure of tumor tissue and the behavioral characteristics of tumor cells, and the results may help improve cancer diagnosis and the development of future targeted cancer therapies.
photo source: In the CC0 Public Domain article, the researchers themselves looked at the biological changes that cells undergo during cancer, most typically the degradation process of the endocrine adhesive molecule E-cadherin, in other words, Cells become less sticky; the researchers say the degradation process of E-calcium mucous proteins is accompanied by changes in the type of cell movement in the tissue, and cancer-prone cells are free to overtake their peers, while endocrine cells are trapped by surrounding cells.
The researchers have long speculated that reduced cell viscosity during tumor occurrence increases the mobility of these cancer cells, and the researchers in this study confirmed this basic hypothesis, while also finding that dense environments can still prevent cancer cells from moving back and forth, in the researchers' view, tumor invasiveness is often significantly affected by the local environment, if this reduces the resistance of surrounding tissue, a single functioning cell may move in groups, the researchers found in the experiment, all types of cell movement seems to lead to cancer metastasis.
Most cancers are developed by the endosome tissue that covers and separates organs, whose function is to protect and support the body's tissue, which does not move in health conditions, and cells in the endocal tissue are a standard example of cell interference research conducted by researchers. This area of research is growing rapidly; this non-movement is due to the mutual barriers between cells, similar to traffic jams in cars, where cancer cells need to have the ability to move around the body in order to metasnap, and their esophysics change during tumors and move away from the behavior of the skin tissue.
Through a study of tumor cells from the body of cancer patients, the researchers found that cancer cells spread in different ways in different environments, and cells with skin esophageal forms were locked into a closed network in which their movement patterns were coordinated and group-based, and the less viscous cells then became more cancerous, as they adhered to As the force decreases, their motor behavior becomes more fluid, and the researchers point out that individual, less viscous cells are isolated into the surrounding tissue, which only occurs when the tissue is not too dense, and that the movement is not as coordinated and synchronized as cells with an endotrified esoteric esoteric type, which is random and not in harmony with adjacent cells.
In order to translate the results into improved treatment for cancer patients, later researchers need to conduct more in-depth research to find out which migration patterns promote metastasis of cancer cells, which is critical for later scientists to develop new treatments for metastasis cancer.
() Original source: Olga Ilina et al, Cell-cell adhesion and 3D matrixement judge jamming transitions in breast cancer invasion, Nature Cell Biology (2020). DOI: 10.1038/s41556-020-0552-6.